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N-Acetyl chitohexaose (NACOS-6) was able to display chemotactic response of human neutrophils in vitro. In order to analyze the mechanism, a series of chemotaxis studies by means of neutrophils treated with inhibitors of phospholipase A2, cyclooxygenase, or lipoxygenase to NACOS-6 was conducted. The treatment of neutrophils with inhibitors of phospholipase A2 or cyclooxygenase resulted in decrease of number of migrated cells. However, the lipoxygenase inhibitors did not exhibit the same effect. On the other hand, the treatment of neutrophils with inhibitors of phospholipase A2 or lipoxygenase resulted in decrease of chemotactic response to Formyl-Met-Leu-Phe (FMLP), although the cyclooxygenase inhibitors did not inhibit chemotaxis of neutrophils. Neutrophils added to exogenous prostaglandin E2 (PGE2) caused an enhanced chemotactic response to NACOS-6. These results indicate that the mechanism of chemotactic response to NACOS-6 was different from that of FMLP, and that the response was enhanced by PGE2 released from the neutrophils with stimulation of NACOS-6.
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
December 1989,
American journal of respiratory cell and molecular biology,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
July 1984,
Blood,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
April 1981,
Journal of immunology (Baltimore, Md. : 1950),
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
January 1972,
Immunological communications,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
December 1990,
Blood,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
January 1993,
British journal of anaesthesia,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
January 1986,
Journal de pharmacologie,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
August 1976,
Biochimica et biophysica acta,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
August 1987,
Biochemical and biophysical research communications,
A Tokoro, and
K Suzuki, and
T Matsumoto, and
T Mikami, and
S Suzuki, and
M Suzuki
September 1984,
Federation proceedings,
