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In this investigation, transport of endoperoxides from the vessel wall to the platelets in an in vivo model for the induction and quantification of platelet thrombosis is described. Thrombi are induced in a branch of the mesenteric artery of the male white Wistar rat through topical superfusion of adenosine diphosphate solutions following focal de-endothelialization by means of a small electrical current in two groups, comparing untreated rats to acetylsalicylic acid (ASA) treated ones. In the latter group the cyclooxygenase activity of the platelets is completely inhibited but not so that of the endothelial cells. In both groups arachidonic acid enhances adenosine diphosphate induced arterial platelet thrombosis most likely through the conveyance of endoperoxides generated in the vessel wall to the platelets as thromboxane synthetase antagonists as well as thromboxane receptor blocking agents completely inhibit this enhancement in both groups. Furthermore it is demonstrated that ASA treated animals show an increased propensity to thrombosis induced by adenosine diphosphate.
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
January 1976,
Journal of the Royal College of Physicians of London,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
January 1975,
Acta clinica Belgica,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
January 1984,
Advances in experimental medicine and biology,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
May 1986,
Clinics in haematology,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
January 1985,
Advances in prostaglandin, thromboxane, and leukotriene research,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
February 2021,
Journal of thrombosis and haemostasis : JTH,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
January 2003,
Bulletin de l'Academie nationale de medecine,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
May 1995,
Thrombosis and haemostasis,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
February 1988,
Experientia,
R H Bourgain, and
R Andries, and
K Decuyper, and
P Braquet
May 1986,
Clinics in haematology,
