BIOMAT Database Logo BIOMAT Database Logo

Human papillomavirus DNA in head and neck squamous cell carcinomas in the Free State, South Africa. 2020

Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Division of Virology, University of the Free State, Bloemfontein, South Africa.

Human papillomaviruses (HPVs) have been associated with a subset of head and neck squamous cell carcinomas (HNSCCs). The aim of this study was to determine the prevalence of HPV DNA in archived formalin-fixed paraffin-embedded tissue from patients with histologically confirmed HNSCCs in a South African cohort. A nested PCR was used for the detection of HPV DNA targeting the L1 gene. Positive samples were confirmed using an in-house hemi-nested PCR targeting the E6 gene and genotyped by sequence determination of amplicons. HPV DNA was detected in 57/780 (7.3%) samples, with the highest prevalence being in the sinonasal tract (16.0%) and oropharynx (10.8%). HPV16 was the most frequently detected type, being found in 26/57 (45.6%) positive samples. The prevalence of HPV DNA in HNSCCs found in this study was lower than that found in developed countries.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D004279 DNA, Viral Deoxyribonucleic acid that makes up the genetic material of viruses. Viral DNA
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006258 Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) Cancer of Head and Neck,Head Cancer,Head Neoplasm,Head and Neck Cancer,Head and Neck Neoplasm,Neck Cancer,Neck Neoplasm,Neck Neoplasms,Neoplasms, Upper Aerodigestive Tract,UADT Neoplasm,Upper Aerodigestive Tract Neoplasm,Upper Aerodigestive Tract Neoplasms,Cancer of Head,Cancer of Neck,Cancer of the Head,Cancer of the Head and Neck,Cancer of the Neck,Head Neoplasms,Head, Neck Neoplasms,Neoplasms, Head,Neoplasms, Head and Neck,Neoplasms, Neck,UADT Neoplasms,Cancer, Head,Cancer, Neck,Cancers, Head,Cancers, Neck,Head Cancers,Neck Cancers,Neoplasm, Head,Neoplasm, Neck,Neoplasm, UADT,Neoplasms, UADT
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077195 Squamous Cell Carcinoma of Head and Neck The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer. HNSCC,Head And Neck Squamous Cell Carcinomas,Hypopharyngeal Squamous Cell Carcinoma,Laryngeal Squamous Cell Carcinoma,Oral Cavity Squamous Cell Carcinoma,Oral Squamous Cell Carcinoma,Oral Squamous Cell Carcinomas,Oral Tongue Squamous Cell Carcinoma,Oropharyngeal Squamous Cell Carcinoma,Squamous Cell Carcinoma of Larynx,Squamous Cell Carcinoma of the Larynx,Squamous Cell Carcinoma of the Mouth,Squamous Cell Carcinoma of the Nasal Cavity,Carcinoma, Squamous Cell of Head and Neck,Head and Neck Squamous Cell Carcinoma,Squamous Cell Carcinoma of the Head and Neck,Squamous Cell Carcinoma, Head And Neck
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D013019 South Africa A republic in southern Africa, the southernmost part of Africa. It has three capitals: Pretoria (administrative), Cape Town (legislative), and Bloemfontein (judicial). Officially the Republic of South Africa since 1960, it was called the Union of South Africa 1910-1960. Republic of South Africa,Union of South Africa

Related Publications

Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus DNA types in squamous cell carcinomas of the head and neck.
June 1991, Oral surgery, oral medicine, and oral pathology,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus in head and neck squamous cell carcinomas in a South African cohort.
December 2018, Papillomavirus research (Amsterdam, Netherlands),
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Cutaneous human papillomavirus in head and neck squamous cell carcinomas.
August 2009, Cancer investigation,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus detection in head and neck squamous cell carcinomas.
November 2010, Advances in anatomic pathology,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus DNA sequences in cell lines derived from head and neck squamous cell carcinomas.
March 1991, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus in head and neck squamous cell carcinomas in nonsmokers.
May 1997, Archives of otolaryngology--head & neck surgery,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
[Role of human papillomavirus in head and neck squamous cell carcinomas].
April 2017, Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Human papillomavirus-positive basaloid squamous cell carcinomas of the head and neck.
October 2010, Human pathology,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
In situ hybridization of papillomavirus DNA in head and neck squamous cell carcinomas.
August 1987, Archives of otolaryngology--head & neck surgery,
Atang Bulane, and Dominique Goedhals, and Riaz Y Seedat, and Jacqueline Goedhals, and Felicity Burt
Transcription of human papillomavirus oncogenes in head and neck squamous cell carcinomas.
May 2020, Vaccine,
Copied contents to your clipboard!