We propose a new phenomenological approach to establish QCD factorization of jet cross sections in the heavy-ion environment. Starting from a factorization formalism in proton-proton collisions, we introduce medium modified jet functions to capture the leading interaction of jets with the hot and dense QCD medium. A global analysis using a Monte Carlo sampling approach is performed in order to reliably determine the new jet functions from the nuclear modification factor of inclusive jets at the LHC. We find that gluon jets are significantly more suppressed due to the presence of the medium than quark jets. In addition, we observe that the jet radius dependence is directly related to the relative suppression of quark and gluon jets. Our approach may help to improve the extraction of medium properties from data.