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In the intestinal mucosa, diamine oxidase (DAO) seems to be involved in a feed-back regulation mechanism for the termination of proliferation. Therefore, we studied the DAO activity in large bowel tumors and in the non-affected mucosa of these patients in comparison with patients having a normal large mucosa. The DAO activity in the tumor tissue itself was diminished by 85% as compared to the surrounding mucosa. Comparing the colonic mucosa of normal and tumor bearing individuals, the DAO activity in cancer patients was diminished by 22%, while it was elevated by 64% in patients with polyps (biphasic response of the DAO activity). Histologically proven hyperproliferative mucosal alterations were indicated by a reduced DAO activity with 75% sensitivity and 42% specificity. It remains open whether this limited specificity may indicate a more sensitive reaction of the DAO activity to proliferative mucosal alterations than the histological examinations.
R Mennigen, and
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B Krakamp, and
A Elbers, and
B Amoei, and
M Kessebohm, and
H Sommer
March 1959,
Acta physiologica Scandinavica,
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H Sommer
February 2018,
Journal of physiology and biochemistry,
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April 1990,
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May 1989,
Hinyokika kiyo. Acta urologica Japonica,
R Mennigen, and
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H Sommer
November 1984,
Digestive diseases and sciences,
R Mennigen, and
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October 1985,
Agents and actions,
R Mennigen, and
J Kusche, and
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A Elbers, and
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M Kessebohm, and
H Sommer
April 1986,
Agents and actions,
R Mennigen, and
J Kusche, and
B Krakamp, and
A Elbers, and
B Amoei, and
M Kessebohm, and
H Sommer
January 1989,
The International journal of biological markers,
R Mennigen, and
J Kusche, and
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A Elbers, and
B Amoei, and
M Kessebohm, and
H Sommer
February 2019,
Clinical nutrition (Edinburgh, Scotland),
R Mennigen, and
J Kusche, and
B Krakamp, and
A Elbers, and
B Amoei, and
M Kessebohm, and
H Sommer
July 1973,
Acta physiologica Scandinavica,
