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A phase II study of FT-207 suppository (Futraful Suppository) for head and neck cancer was conducted at the Kagoshima University Hospital Dept. of Otorhinolaryngology and its 6 affiliated hospitals. Forty cases with head and neck cancer were entered in the trial, of which 37 were perfectly evaluable. Partial response (PR) (16.7%) was achieved in one of 6 patients with maxillary cancer, in 2 of 9 cases with oral cancer (22.2%), in one of 7 with laryngeal cancer (14.3%), in 3 of 13 with pharyngeal cancer, while 2 of the same 13 achieved a complete response (CR) (38.5%), for a total response rate of 24.3%. FT-207 suppository was continuously administered as standard, at a dose of 750 mg each twice daily, or 1,500 mg/day. The response rate was dose-dependent; 2 CR cases with a total dose of 105 g for administration over a total period of more than 150 days. Adverse effects appearing in 35.0% of the overall were mainly anorexia, nausea and vomiting; none of them, however, were serious.
M Ohyama, and
M Matsumura, and
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S Kamachi
February 1987,
American journal of clinical oncology,
M Ohyama, and
M Matsumura, and
K Katsuta, and
T Nobori, and
S Furuta, and
S Matsunaga, and
A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
September 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Ohyama, and
M Matsumura, and
K Katsuta, and
T Nobori, and
S Furuta, and
S Matsunaga, and
A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
July 1988,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Ohyama, and
M Matsumura, and
K Katsuta, and
T Nobori, and
S Furuta, and
S Matsunaga, and
A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
June 1984,
American journal of clinical oncology,
M Ohyama, and
M Matsumura, and
K Katsuta, and
T Nobori, and
S Furuta, and
S Matsunaga, and
A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
March 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Ohyama, and
M Matsumura, and
K Katsuta, and
T Nobori, and
S Furuta, and
S Matsunaga, and
A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
April 1988,
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M Ohyama, and
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A Uchizono, and
T Hanada, and
I Moriyama, and
S Kamachi
January 1990,
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M Ohyama, and
M Matsumura, and
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April 1999,
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M Ohyama, and
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February 1983,
Nihon Gan Chiryo Gakkai shi,
M Ohyama, and
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A Uchizono, and
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February 1986,
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