BIOMAT Database Logo BIOMAT Database Logo

A non-enzymatic glucose sensor enabled by bioelectronic pH control. 2019

Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Department of Electrical and Computer Engineering, University of California Santa Cruz, Santa Cruz, CA, 95064, USA.

Continuous glucose monitoring from sweat and tears can improve the quality of life of diabetic patients and provide data for more accurate diagnosis and treatment. Current continuous glucose sensors use enzymes with a one-to-two week lifespan, which forces periodic replacement. Metal oxide sensors are an alternative to enzymatic sensors with a longer lifetime. However, metal oxide sensors do not operate in sweat and tears because they function at high pH (pH > 10), and sweat and tears are neutral (pH = 7). Here, we introduce a non-enzymatic metal oxide glucose sensor that functions in neutral fluids by electronically inducing a reversible and localized pH change. We demonstrate glucose monitoring at physiologically relevant levels in neutral fluids mimicking sweat, and wireless communication with a personal computer via an integrated circuit board.

UI MeSH Term Description Entries
D010087 Oxides Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides. Oxide
D010165 Palladium A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.
D011788 Quality of Life A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral, social environment as well as health and disease. HRQOL,Health-Related Quality Of Life,Life Quality,Health Related Quality Of Life
D003035 Cobalt A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis. Cobalt-59,Cobalt 59
D003920 Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D004566 Electrodes Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum. Anode,Anode Materials,Cathode,Cathode Materials,Anode Material,Anodes,Cathode Material,Cathodes,Electrode,Material, Anode,Material, Cathode
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006046 Gold A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations

Related Publications

Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Dual functional rhodium oxide nanocorals enabled sensor for both non-enzymatic glucose and solid-state pH sensing.
July 2018, Biosensors & bioelectronics,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Cellulose microfluidic pH boosting on copper oxide non-enzymatic glucose sensor strip for neutral pH samples.
February 2023, Talanta,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Non-enzymatic electrochemical glucose sensor based on NiMoO₄ nanorods.
April 2015, Nanotechnology,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
A novel non-enzymatic glucose sensor modified with Fe2O3 nanowire arrays.
October 2011, The Analyst,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Synthesis of Novel Pd Nanosponges for Non-Enzymatic Glucose Sensor.
December 2020, Journal of nanoscience and nanotechnology,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Performance-Enhanced Non-Enzymatic Glucose Sensor Based on Graphene-Heterostructure.
December 2019, Sensors (Basel, Switzerland),
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Non-enzymatic glucose sensor based on a g-C3N4/NiO/CuO nanocomposite.
March 2021, Analytical biochemistry,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
A non-enzymatic urine glucose sensor with 2-D photonic crystal hydrogel.
November 2016, Analytical and bioanalytical chemistry,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
Non-Enzymatic Glucose Sensor Based on 3D Graphene Oxide Hydrogel Crosslinked by Various Diamines.
November 2015, Journal of nanoscience and nanotechnology,
Xenofon Strakosas, and John Selberg, and Pattawong Pansodtee, and Nebyu Yonas, and Pattawut Manapongpun, and Mircea Teodorescu, and Marco Rolandi
MWCNT-ruthenium oxide composite paste electrode as non-enzymatic glucose sensor.
January 2012, Biosensors & bioelectronics,
Copied contents to your clipboard!