Two-year abatacept retention rate in clinical practice in the French ACTION cohort. 2019

Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
Université Paris-Sud, AP-HP, Hôpitaux universitaires Paris-Sud, Inserm UMR1184, 94270 Le Kremlin-Bicêtre, France. Electronic address: xavier.mariette@aphp.fr.

Abatacept retention rates were evaluated in the French cohort in the prospective ACTION study (2010-2013), which included patients with moderate-to-severe rheumatoid arthritis managed in everyday clinical practice and started on intravenous abatacept therapy. Two-year abatacept retention rates were evaluated in 455 patients classified according to treatment line, body mass index (BMI), and status for rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA). After 2 years, the overall abatacept retention rate was 44%. The retention rate was non-significantly higher in the patients with vs. without a history of unresponsiveness to at least one biologic (48.1% vs. 41.8%, respectively). No significant retention rate differences were found across BMI categories (444 patients; <25, 45.5%; ≥25 to <30, 48.9%; and ≥30, 36.6%). Neither were any significant differences demonstrated according to RF and ACPA status (RF+ and ACPA+, 45.7%; RF+ or ACPA+, 43.8%; and FR- and ACPA-, 39.1%). The 44% 2-year retention rate in the French ACTION cohort supports the usefulness of abatacept therapy. In this study, retention was not associated with treatment line, BMI, or antibody status.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010349 Patient Compliance Voluntary cooperation of the patient in following a prescribed regimen. Client Adherence,Client Compliance,Non-Adherent Patient,Patient Adherence,Patient Cooperation,Patient Noncompliance,Patient Non-Adherence,Patient Non-Compliance,Patient Nonadherence,Therapeutic Compliance,Treatment Compliance,Adherence, Client,Adherence, Patient,Client Compliances,Compliance, Client,Compliance, Patient,Compliance, Therapeutic,Compliance, Treatment,Cooperation, Patient,Non Adherent Patient,Non-Adherence, Patient,Non-Adherent Patients,Non-Compliance, Patient,Nonadherence, Patient,Noncompliance, Patient,Patient Non Adherence,Patient Non Compliance,Patient, Non-Adherent,Therapeutic Compliances,Treatment Compliances
D011446 Prospective Studies Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group. Prospective Study,Studies, Prospective,Study, Prospective
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D005260 Female Females
D005500 Follow-Up Studies Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease. Followup Studies,Follow Up Studies,Follow-Up Study,Followup Study,Studies, Follow-Up,Studies, Followup,Study, Follow-Up,Study, Followup
D005602 France A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris. Corsica,Saint Pierre and Miquelon,Miquelon and Saint Pierre,Miquelon and St. Pierre,St. Pierre and Miquelon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
March 2024, Clinical and experimental rheumatology,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
April 2020, Wiener medizinische Wochenschrift (1946),
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
November 2019, Clinical rheumatology,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
May 1982, The Journal of prosthetic dentistry,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
August 1991, International journal of paediatric dentistry,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
November 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
September 2023, Clinical rheumatology,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
October 2018, Rheumatology international,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
January 2012, Reumatologia clinica,
Xavier Mariette, and Thierry Schaeverbeke, and Philippe Gaudin, and Mélanie Chartier, and Julia Heitzmann, and Virginie Vannier-Moreau, and Pascal Hilliquin, and Alain Cantagrel
October 2022, Clinical rheumatology,
Copied contents to your clipboard!