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Genetic diversity of HLA system in two populations from Querétaro, Mexico: Querétaro city and rural Querétaro. 2020
Julio César Martínez-Álvarez, and
Rodrigo Barquera, and
Diana Iraíz Hernández-Zaragoza, and
Alicia Bravo-Acevedo, and
Stephen Clayton, and
Esteban Arrieta-Bolaños, and
Alexander Immel, and
Gamaliel Benítez-Arvizu, and
María Araceli Arrazola-García, and
Vicencio Juárez-Barreto, and
María Del Rosario Vega-Martínez, and
Francisco Juárez-Nicolás, and
Ariadna Berenice Escutia-González, and
Virginia Martínez-Bezies, and
Raquel García-Álvarez, and
Norma Salgado-Galicia, and
Joaquín Zúñiga, and
Edmond J Yunis, and
Carolina Bekker-Méndez, and
Julio Granados
HLA Laboratory, Central Blood Bank, Hospital de Especialidades, Unidad Médica de Alta Especialidad (UMAE) Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico.
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 88 Mexicans from the state of Querétaro living in the city of Querétaro (N = 45) and rural communities (N = 43), to obtain information regarding allelic and haplotypic frequencies. We find that the most frequent haplotypes in the state of Querétaro include seven Native American, two European and one Asian haplotype. Admixture estimates revealed that the main genetic components in the state of Querétaro are Native American (51.82 ± 4.42% by ML; 42.61% of Native American haplotypes) and European (48.18 ± 3.55% by ML; 46.02% of European haplotypes), with a virtually absent African genetic component (0.00 ± 4.25% by ML; 4.55% of African haplotypes).
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