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Significant structural alterations of the axillary lymph nodes and spleens were revealed by histomorphometry following intraperitoneal injection of BCG into young adult BALB/c mice. The relative proportions of the germinal center areas were increased in lymph nodes as well as in spleens. The overall proportion of the B cell areas, however, showed a significant increase only in the spleens, compared to a significant reduction in the lymph nodes. By contrast, T cell areas appeared significantly reduced in the spleens, while their size was almost doubled in the lymph nodes. The labeling index in the lymph node paracortical areas was also doubled autoradiographically. The structural changes in the lymph nodes and spleens differed not only in quality, but also in their time course. In lymph nodes, the altered proportions of the T and B cell areas persisted from the second through the sixth week after BCG treatment. By contrast, structural changes in the spleen began to subside 2 weeks after treatment, and after 6 weeks the proportions of the T and B cell areas in the spleen had returned to normal. These quantitative morphologic findings suggest a difference in the functional roles of lymph nodes and spleen in the systemic immune response to BCG.
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
May 1979,
Pathology, research and practice,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
August 1979,
The Anatomical record,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
January 1969,
Rivista di biologia,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
December 1997,
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
December 2005,
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
January 1981,
Annales de pathologie,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
January 1991,
Scandinavian journal of immunology,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
April 1997,
Immunological reviews,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
January 1981,
Developmental and comparative immunology,
E M Meyer, and
K Wilsmann, and
W Schlake, and
E Grundmann
January 1976,
Advances in experimental medicine and biology,
