Forty patients with unstable angina were randomized to therapy with intravenous nitroglycerin (NTG) or nitroprusside (NTP). Invasive hemodynamic measurements were compared in both treatment groups and were used in concert with serial radionuclide monitoring of left ventricular function as patients were titrated to a therapeutic dose. Of the 22 patients randomized to intravenous NTG, there were 18 responders. Cardiac output significantly increased 28%, from 5.0 to 6.5 L/min at maximum effect. Mean pulmonary capillary wedge pressure (PCWP) decreased from 19 to 12 mm Hg. Mean arterial pressure decreased 10% and heart rate was unchanged (82 beats/min pre-treatment, 81 beats/min post-treatment). Radionuclide determined ejection fraction (EF) increased an average of 0.13, from 0.45 to 0.58. Peak filling rate paralleled increases in EF, increasing from 2.2 to 3.4 EDV/sec at peak level. Hemodynamic and radionuclide responses in the intravenous NTP group were compared to those with NTG. Of 18 patients randomized to NTP, 15 responders increased cardiac output from 5.1 to 6.8 L/min, a 35% increase. PCWP was 18 mm Hg at baseline and 10 mm Hg at peak effect. Mean arterial pressure decreased 13%, which was not significantly different from the NTG group. Heart rate response was identical to that in the NTG group. Ejection fraction increased an average of 0.17, from 0.43 to 0.60. Similar improvements were seen in peak filling rate (2.09 to 3.3 EDV/sec). There were no baseline differences between the NTG and NTP groups. In these patients NTG and NTP demonstrated equal efficacy, with the majority of patients showing substantial improvement in acute hemodynamics and left ventricular function with either agent.(ABSTRACT TRUNCATED AT 250 WORDS)