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Boosting Fmoc Solid-Phase Peptide Synthesis by Ultrasonication. 2019
Francesco Merlino, and
Stefano Tomassi, and
Ali M Yousif, and
Anna Messere, and
Luciana Marinelli, and
Paolo Grieco, and
Ettore Novellino, and
Sandro Cosconati, and
Salvatore Di Maro
Dipartimento di Farmacia , Università degli Studi di Napoli "Federico II" , via D. Montesano 49 , 80131 Naples , Italy.
We investigated the ultrasonication-mediated effects on the Fmoc-based solid-phase peptide synthesis (SPPS). Our study culminated with the development of an ultrasound-assisted strategy (US-SPPS) that allowed for the synthesis of different biologically active peptides (up to 44-mer), with a remarkable savings of material and reaction time. Noteworthy, ultrasonic irradiation did not exacerbate the main side reactions and improved the synthesis of peptides endowed with "difficult sequences", placing the US-SPPS among the current high-efficient peptide synthetic strategies.
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