BIOMAT Database Logo BIOMAT Database Logo

Neo-clerodane diterpenoids from aerial parts of Salvia hispanica L. and their cardioprotective effects. 2019

Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, PR China; College of Pharmaceutical Science, Dali University, Dali, 671000, PR China.

Ten undescribed neo-clerodane diterpenoids, named hispanins A-J, together with six known ones, were isolated from the aerial parts of Salvia hispanica L. Their structures were established by extensive spectroscopic analysis. The absolute configurations of the undescribed compounds were determined by the ECD data and single crystal X-ray diffraction analysis. Hispanins B and C represented the first neo-clerodane diterpenoids with a unique oxygen bridge between C-19 and C-20. All isolated compounds were evaluated for their protective effects against H2O2-induced cardiomyocyte injury. Five of these compounds showed significant cardioprotective effects.

UI MeSH Term Description Entries
D002316 Cardiotonic Agents Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE). Cardiac Stimulant,Cardiac Stimulants,Cardioprotective Agent,Cardioprotective Agents,Cardiotonic,Cardiotonic Agent,Cardiotonic Drug,Inotropic Agents, Positive Cardiac,Myocardial Stimulant,Myocardial Stimulants,Cardiotonic Drugs,Cardiotonics,Agent, Cardioprotective,Agent, Cardiotonic,Drug, Cardiotonic,Stimulant, Cardiac,Stimulant, Myocardial
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D045785 Diterpenes, Clerodane A group of DITERPENES cyclized into 2-rings with a side-chain. Clerodane Diterpene,Clerodane Diterpenoid,Clerodane Diterpenoids,Neoclerodane Diterpene,Neoclerodane Diterpenes,Neoclerodanes,Clerodane,Clerodane Diterpenes,Clerodanes,Diterpene, Clerodane,Diterpene, Neoclerodane,Diterpenes, Neoclerodane,Diterpenoid, Clerodane,Diterpenoids, Clerodane
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus
D027544 Salvia A genus in the mint family (LAMIACEAE). Salvias
D032383 Myocytes, Cardiac Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC). Cardiomyocytes,Muscle Cells, Cardiac,Muscle Cells, Heart,Cardiac Muscle Cell,Cardiac Muscle Cells,Cardiac Myocyte,Cardiac Myocytes,Cardiomyocyte,Cell, Cardiac Muscle,Cell, Heart Muscle,Cells, Cardiac Muscle,Cells, Heart Muscle,Heart Muscle Cell,Heart Muscle Cells,Muscle Cell, Cardiac,Muscle Cell, Heart,Myocyte, Cardiac
D035261 Plant Components, Aerial The above-ground plant without the roots. Aerial Parts, Plant,Aerial Plant Components,Aerial Part, Plant,Aerial Plant Component,Component, Aerial Plant,Components, Aerial Plant,Part, Plant Aerial,Parts, Plant Aerial,Plant Aerial Part,Plant Aerial Parts,Plant Component, Aerial

Related Publications

Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L.
September 2021, Chemistry & biodiversity,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
New neo-clerodane diterpenoids with neurotrophic activity from the aerial parts of Salvia tiliifolia.
November 2017, Fitoterapia,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Neo-clerodane and abietane diterpenoids with neurotrophic activities from the aerial parts of Salvia leucantha Cav.
June 2018, Fitoterapia,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Phytotoxic neo-clerodane diterpenoids from the aerial parts of Scutellaria barbata.
March 2020, Phytochemistry,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Six New neo-Clerodane Diterpenoids from Aerial Parts of Scutellaria barbata and Their Cytotoxic Activities.
November 2018, Planta medica,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Antinociceptive and anxiolytic-like effects of a neo-clerodane diterpene from Salvia semiatrata aerial parts.
December 2020, Pharmaceutical biology,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
neo-Clerodane diterpenoids from the aerial parts of Teucrium fruticans cultivated in China.
November 2015, Phytochemistry,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
neo-Clerodane Diterpenoids from the Aerial Parts of Scutellaria barbata with Anti-Inflammatory Activity.
December 2021, Chemistry & biodiversity,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae).
April 2016, Journal of natural medicines,
Min Fan, and Dan Luo, and Li-Yan Peng, and Xiao-Nian Li, and Xing-De Wu, and Xu Ji, and Qin-Shi Zhao
neo-Clerodane Diterpenoids and Other Constituents of Salvia filipes.
October 2016, Journal of natural products,
Copied contents to your clipboard!