Biomaterial Database

Susceptibility of Schistosoma mansoni prevalent in Saudi Arabia to oxamniquine in experimentally infected mice. 1988

A M Amin, and E G Mikhail

Medical Parasitology Department, Faculty of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.

The therapeutic efficiency of oxamniquine against the local strain of Schistosoma mansoni was investigated in experimentally infected mice. The drug was administered orally using a human-equivalent dose of 20 mg kg-1 day-1 for 3 consecutive days (total dose of 60 mg kg-1). Oxamniquine proved to be very effective as indicated by hepatic shift, oogram changes, complete elimination of adult worms and eradication of faecal eggs.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D008815	Mice, Inbred Strains	Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.	Inbred Mouse Strains,Inbred Strain of Mice,Inbred Strain of Mouse,Inbred Strains of Mice,Mouse, Inbred Strain,Inbred Mouse Strain,Mouse Inbred Strain,Mouse Inbred Strains,Mouse Strain, Inbred,Mouse Strains, Inbred,Strain, Inbred Mouse,Strains, Inbred Mouse
D009600	Nitroquinolines	Quinolines substituted in any position by one or more nitro groups.
D010073	Oxamniquine	An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)	Oxaminiquine,UK-4271,UK 4271,UK4271
D010270	Parasite Egg Count	Determination of parasite eggs in feces.	Count, Parasite Egg,Counts, Parasite Egg,Egg Count, Parasite,Egg Counts, Parasite,Parasite Egg Counts
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D005260	Female		Females
D000284	Administration, Oral	The giving of drugs, chemicals, or other substances by mouth.	Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia

Related Publications

A M Amin, and E G Mikhail

[Effect of oxamniquine on Schistosoma mansoni in experimentally infected mice].

January 1979, Revista do Instituto de Medicina Tropical de Sao Paulo,

A M Amin, and E G Mikhail

Treatment of Schistosoma mansoni infection with oxamniquine in Riyadh, Saudi Arabia.

December 1985, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ),

A M Amin, and E G Mikhail

Lethal effect of oxamniquine and praziquantel on mice experimentally infected with Schistosoma mansoni.

January 1995, Revista do Instituto de Medicina Tropical de Sao Paulo,

A M Amin, and E G Mikhail

[Action of oxamniquine on Schistosoma mansoni in mice experimentally infected with a strain from Kenya].

January 1987, Memorias do Instituto Oswaldo Cruz,

A M Amin, and E G Mikhail

MYOPATHY IN MICE EXPERIMENTALLY INFECTED WITH SCHISTOSOMA MANSONI.

January 1965, Transactions of the Royal Society of Tropical Medicine and Hygiene,

A M Amin, and E G Mikhail

Pulmonary lesions in mice experimentally infected with Schistosoma mansoni.

September 1959, The American journal of tropical medicine and hygiene,