-transparent.png){kind=logo}
Three Portuguese water dog siblings, all females aged 5 to 7 months, were killed following a brief period of neurologic disease. Tissues were processed for light and electron microscopy and for biochemical analyses. All pups had membranous cytoplasmic inclusions in neurons throughout the brain and spinal cord. Cytoplasmic vacuoles were present in cells of many organs outside the nervous system. GM1 ganglioside in brain was markedly elevated in all three dogs, and beta-galactosidase activity was less than 10% of control values. These findings are similar to those in GM1 gangliosidosis of man and animals although the number of organs and tissues containing vacuolated cells is greater.
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
July 1986,
Archives of neurology,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
May 2001,
Veterinary pathology,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
April 2000,
The Veterinary record,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
January 1978,
Voprosy meditsinskoi khimii,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
April 2016,
Blood,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
January 2006,
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
April 1992,
Rinsho shinkeigaku = Clinical neurology,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
January 1989,
Brain & development,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
November 1978,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
G K Saunders, and
P A Wood, and
R K Myers, and
L G Shell, and
R Carithers
October 1998,
AJNR. American journal of neuroradiology,
