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Rat peritoneal macrophages were prelabeled with [3H]arachidonic acid. The release of radioactivity into the medium was increased by treatment with TPA-type tumor promoters, such as TPA, teleocidin and aplysiatoxin, and the non-TPA-type tumor promoter, thapsigargin. Gossypol, at concentrations of 3 and 10 microM, inhibited the release of radioactivity stimulated by both types of tumor promoter, although the mechanism of stimulation of arachidonic acid metabolism is different in the two types of tumor promoter. Stimulation of prostaglandin E2 production by these tumor promoters was also inhibited by treatment with gossypol. Calcium ionophore A23187-stimulated release of radioactivity and prostaglandin E2 production were also inhibited by gossypol treatment. The mechanism of inhibition by gossypol of prostaglandin E2 production is discussed.
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
January 1988,
International journal of immunopharmacology,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
September 1987,
Prostaglandins,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
January 1989,
Anales de la Real Academia Nacional de Medicina,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
November 1984,
The American review of respiratory disease,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
January 1988,
Immunopharmacology,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
December 1980,
Biochemical and biophysical research communications,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
April 1993,
Biochimica et biophysica acta,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
October 1994,
The Journal of biological chemistry,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
July 1997,
Biochimica et biophysica acta,
K Ohuchi, and
M Watanabe, and
N Hirasawa, and
S Tsurufuji, and
T Ozeki, and
H Fujiki
November 1997,
Lipids,
