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Disulfide-Containing Detergents (DCDs) for the Structural Biology of Membrane Proteins. 2019
Dongxiang Xue, and
Tiandan Xu, and
Huixia Wang, and
Meng Wu, and
Ya Yuan, and
Wei Wang, and
Qiwen Tan, and
Fei Zhao, and
Fang Zhou, and
Tao Hu, and
Zhongxing Jiang, and
Zhi-Jie Liu, and
Suwen Zhao, and
Dongsheng Liu, and
Kurt Wüthrich, and
Houchao Tao
iHuman Institute, ShanghaiTech University, Ren Building, 393 Middle Huaxia Road, Pudong New District, Shanghai, 201210, China.
Disulfide-containing detergents (DCDs) are introduced, which contain a disulfide bond in the hydrophobic tail. DCDs form smaller micelles than corresponding detergents with linear hydrocarbon chains, while providing good solubilization and reconstitution of membrane proteins. The use of this new class of detergents in structural biology is illustrated with solution NMR spectra of the human G protein-coupled receptor A2A AR, which is an α-helical protein, and the β-barrel protein OmpX from E. coli.
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