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In the present study, we investigated the interleukin-2 (IL-2) production and the proliferative responses by peripheral blood mononuclear cells (PBMNC) of 23 children suffering from insulin-dependent diabetes mellitus (IDDM). In addition, the presence of circulating activated T lymphocytes expressing the interleukin-2 receptor (IL-2 R) and HLA-DR antigens was evaluated. The patients were tested at hospital admittance, before starting insulin treatment. Decreased IL-2 production by phytohemagglutinin (PHA)-activated PBMNC of IDDM patients was observed when compared to normal donors. In contrast, the proliferative responses of PBMNC to PHA and Con A were in the normal range. The expression of IL-2 R on patient's lymphocytes was not different from that observed in normal donors, whereas the relative and absolute number of HLA-DR+ T cells was increased. These results confirm the presence in IDDM patients of an imbalanced cellular immune response and demonstrate that the IL-2 deficiency is already present at the diagnosis and is not correlated with insulin administration.
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
March 2021,
Journal of basic and clinical physiology and pharmacology,
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
January 1990,
Archives of dermatological research,
M G Roncarolo, and
M Zoppo, and
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C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
January 1997,
British journal of nursing (Mark Allen Publishing),
M G Roncarolo, and
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R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
January 2007,
Primary care companion to the Journal of clinical psychiatry,
M G Roncarolo, and
M Zoppo, and
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C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
June 2003,
The Journal of communicable diseases,
M G Roncarolo, and
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F Cerutti, and
P A Tovo
March 1989,
Diabetes,
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
January 1994,
Pediatric nursing,
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
December 1996,
Veterinary dermatology,
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
October 2022,
Diabetes/metabolism research and reviews,
M G Roncarolo, and
M Zoppo, and
R Bacchetta, and
C Gabiano, and
C Sacchetti, and
F Cerutti, and
P A Tovo
November 2012,
BMC pediatrics,
