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Human alpha-calcitonin gene-related peptide (CGRP) is a substance immunohistochemically present in a number of organ systems; however, the biologic significance of this peptide is uncertain. The present study was undertaken to investigate the effects of CGRP in the feline mesenteric vascular bed under conditions of controlled blood flow. Bolus injections of CGRP decreased mesenteric perfusion pressure in a dose-related fashion. When compared with nitroglycerin, CGRP possesses markedly greater vasodilator activity in the intestinal vascular bed of the cat. Because circulating levels of CGRP have been identified, the present data suggest CGRP may play a role in the regulation of systemic vasomotor tone and regional hemodynamics, as well as involve altered calcium metabolism seen with other calcium-regulating hormones in hypertensive states.
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
December 1988,
British journal of clinical pharmacology,
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
October 1986,
The Journal of investigative dermatology,
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
October 1993,
Biochemical and biophysical research communications,
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
June 1993,
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H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
March 1992,
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H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
September 1988,
Nature,
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
February 2020,
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H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
April 1998,
Sheng li xue bao : [Acta physiologica Sinica],
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
April 1986,
Clinical science (London, England : 1979),
H L Lippton, and
K Lepak, and
G Cohen, and
P Roland, and
P J Kadowitz, and
A L Hyman
July 1985,
Lancet (London, England),
