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Forty-three patients, all male, with limited epidermoid carcinoma of the soft palate and uvula were treated by interstitial implant usually associated with external radiotherapy. Most patients received 50 Gy external irradiation to the oropharynx and neck followed by 20-35 Gy by interstitial iridium-192 wires using either guide gutters or a plastic tube technique. Twelve primary tumors and two recurrences after external irradiation alone had implant only for 65-75 Gy. Total actuarial local control is 92% with no local failures in 34 T1 primary tumors. Only one serious complication was seen. Overall actuarial survival was 60% at 3 years and 37% at 5 years but cause-specific survivals were 81% and 64%. The leading cause of death was other aerodigestive cancer, with an actuarial rate of occurrence of 10% per year after treatment of a soft palate cancer. Interstitital brachytherapy alone or combined with external irradiation is safe, effective management for early carcinoma of the soft palate and uvula but second malignancy is a serious problem.
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
February 1991,
The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
March 1974,
The American journal of roentgenology, radium therapy, and nuclear medicine,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
June 1979,
International journal of radiation oncology, biology, physics,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
April 1986,
Nihon Jibiinkoka Gakkai kaiho,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
January 1918,
Proceedings of the Royal Society of Medicine,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
January 1992,
Head & neck,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
July 1988,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
April 1988,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
October 1984,
International journal of radiation oncology, biology, physics,
B A Esche, and
C M Haie, and
A P Gerbaulet, and
F Eschwege, and
J M Richard, and
D Chassagne
February 2005,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
