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Calorie restriction is known to influence several physiological processes and to alleviate the late effects of radiation exposure such as neoplasm induction and life shortening. However, earlier related studies were limited to acute radiation exposure. Therefore, in this study we examined the influence of chronic low-dose-rate irradiation on lifespan. Young male B6C3F1/Jcl mice were divided randomly into two groups, which were fed either a low-calorie (65 kcal/ week) or high-calorie (95 kcal/week) diet. The latter is comparable to ad libitum feeding. The animals in the irradiated group were continuously exposed to gamma rays for 400 days at 20 mGy/day, resulting in a total dose of 8 Gy. Exposure and calorie restriction were initiated at 8 weeks of age and the diets were maintained for life. The life-shortening effects from chronic whole-body irradiation were compared between the groups. Body weights were reduced in calorie-restricted mice irrespective of radiation treatment. Radiation induced a shortened median lifespan in both groups, but to a greater extent in the calorie-restricted mice. These results suggest that calorie restriction may sensitize mice to chronic low-dose-rate radiation exposure to produce a life-shortening effect rather than alleviating the effects of radiation.
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
February 2004,
Radiation research,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
January 1988,
Frontiers of radiation therapy and oncology,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
November 1967,
Radiation research,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
March 1982,
Radiobiologia, radiotherapia,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
April 1962,
Quarterly progress report. United States. Air Force. Radiation Laboratory, University of Chicago,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
April 2005,
Radiation research,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
May 2007,
International journal of radiation biology,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
June 1992,
La Radiologia medica,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
January 2013,
Nature communications,
Kazumi Yamauchi, and
Tetsuya Ono, and
Yoshiko Ayabe, and
Shun'ichi Hisamatsu, and
Manabu Yoneya, and
Yuki Tsutsumi, and
Jun-Ichiro Komura
March 1971,
The British journal of radiology,
