Double blind comparison of alfentanil N2O and fentanyl N2O for outpatient surgical procedures. 1988

A B Enright, and J B Parker
Department of Anaesthesia, Saskatoon City Hospital, Saskatchewan.

Alfentanil - nitrous oxide and fentanyl - nitrous oxide techniques were compared in outpatients undergoing therapeutic abortion or dilatation and curettage. Thirty patients were studied in each group. Time to awakening was similar in both groups but patients who received alfentanil responded to verbal commands one minute sooner and were alert 1.5 minutes before those who received fentanyl. At ten minutes post anaesthesia the recovery scores were the same for both groups. Patients who received alfentanil were not street-worthy earlier than those who received fentanyl. During the procedure approximately two thirds of the patients moved. This movement was vigorous in 23 per cent of the patients who received alfentanil and in 30 per cent of those given fentanyl. We conclude that: (1) a more flexible dosage schedule is required in order to prevent disturbing movement of the patient during the procedure and (2) patients who received alfentanil were not street-worthy earlier than those who were given fentanyl.

UI MeSH Term Description Entries
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009609 Nitrous Oxide Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream. Laughing Gas,Nitrogen Protoxide,Gas, Laughing,Oxide, Nitrous
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D002986 Clinical Trials as Topic Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries. Clinical Trial as Topic
D004107 Dilatation and Curettage Dilatation of the cervix uteri followed by a scraping of the endometrium with a curette. Curettage and Dilatation,Dilatation & Curettage
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D005260 Female Females
D005283 Fentanyl A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078) Phentanyl,Duragesic,Durogesic,Fentanest,Fentanyl Citrate,Fentora,R-4263,Sublimaze,Transmucosal Oral Fentanyl Citrate,R 4263,R4263
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000029 Abortion, Legal Termination of pregnancy under conditions allowed under local laws. (POPLINE Thesaurus, 1991) Abortion on Demand,Abortions, Legal,Legal Abortion,Legal Abortions

Related Publications

A B Enright, and J B Parker
August 1984, British journal of anaesthesia,
A B Enright, and J B Parker
September 1991, Canadian journal of anaesthesia = Journal canadien d'anesthesie,
A B Enright, and J B Parker
February 1985, Anaesthesia and intensive care,
A B Enright, and J B Parker
January 1986, Anesthesiology,
A B Enright, and J B Parker
January 2000, Journal of neurosurgical anesthesiology,
A B Enright, and J B Parker
September 1987, European journal of anaesthesiology,
A B Enright, and J B Parker
January 1982, Acta anaesthesiologica Belgica,
A B Enright, and J B Parker
July 1996, Journal of the Formosan Medical Association = Taiwan yi zhi,
A B Enright, and J B Parker
October 1994, Acta anaesthesiologica Scandinavica,
Copied contents to your clipboard!