Dysregulations of follicular helper T cells through IL-21 pathway in age-related macular degeneration. 2019

Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Department of Ophthalmology, General Hospital of Guangzhou Military Command of PLA, Guangzhou, China; Southern Medical University, Guangzhou, China.

Age-related macular degeneration (AMD) is the most common cause of vision loss in the aged population. Aging and inflammation are thought to promote AMD pathogenesis in people with genetic predisposition. Follicular helper T (Tfh) cells play critical roles in inflammatory responses. Here, we investigated circulating Tfh cells in AMD patients. Circulating Tfh cells were defined as CXCR5+ CD4 T cells. Data showed that patients with the wet-type AMD presented significantly higher levels of Tfh cells than non-AMD controls. Interestingly, the Tfh cells from dry and wet AMD patients also presented significantly higher ICOS and PD-1 expression, together with higher IL-17 and IL-21 expression directly ex vivo and following PMA/ionomycin stimulation. The expression of IFNg and IL-10, on the other hand, was not different between Tfh cells from AMD patients and their counterparts in non-AMD controls. Functional analysis revealed that Tfh cells from AMD patients were better at inducing the production of IgG and IgA, and this effect was in an IL-21-dependent manner. Together, we demonstrated that the circulating Tfh cell responses were dysregulated in AMD patients.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007371 Interferon-gamma The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D007378 Interleukins Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli. Interleukin
D008268 Macular Degeneration Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms. Maculopathy,Maculopathy, Age-Related,Age-Related Macular Degeneration,Age-Related Maculopathies,Age-Related Maculopathy,Macular Degeneration, Age-Related,Macular Dystrophy,Maculopathies, Age-Related,Age Related Macular Degeneration,Age Related Maculopathies,Age Related Maculopathy,Age-Related Macular Degenerations,Degeneration, Macular,Dystrophy, Macular,Macular Degeneration, Age Related,Macular Degenerations,Macular Dystrophies,Maculopathies,Maculopathy, Age Related
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005260 Female Females
D006377 T-Lymphocytes, Helper-Inducer Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions. Helper Cell,Helper Cells,Helper T Cell,Helper-Inducer T-Lymphocytes,Inducer Cell,Inducer Cells,T-Cells, Helper-Inducer,T-Lymphocytes, Helper,T-Lymphocytes, Inducer,Helper T-Cells,Cell, Helper T,Cells, Helper T,Helper Inducer T Lymphocytes,Helper T Cells,Helper T-Cell,Helper T-Lymphocyte,Helper T-Lymphocytes,Helper-Inducer T-Cell,Helper-Inducer T-Cells,Helper-Inducer T-Lymphocyte,Inducer T-Lymphocyte,Inducer T-Lymphocytes,T Cell, Helper,T Cells, Helper,T Cells, Helper Inducer,T Lymphocytes, Helper,T Lymphocytes, Helper Inducer,T Lymphocytes, Inducer,T-Cell, Helper,T-Cell, Helper-Inducer,T-Cells, Helper,T-Lymphocyte, Helper,T-Lymphocyte, Helper-Inducer,T-Lymphocyte, Inducer
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
January 2010, International immunology,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
October 2016, Danish medical journal,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
December 2018, BMC immunology,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
August 2023, Diagnostics (Basel, Switzerland),
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
January 2020, Frontiers in immunology,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
April 2017, Scientific reports,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
September 2019, Cell reports,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
January 2013, PloS one,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
December 2016, The Journal of general virology,
Qiaowei Wu, and Baoyi Liu, and Ling Yuan, and Qingsheng Peng, and Lin Cheng, and Pingting Zhong, and Xiaohong Yang, and Honghua Yu
August 2023, International journal of molecular sciences,
Copied contents to your clipboard!