BIOMAT Database Logo BIOMAT Database Logo

Monoterpene glycosides with anti-inflammatory activity from Paeoniae Radix. 2019

Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drug Research, Jinan University, Guangzhou 510632, China.

Six new monoterpene glycosides, named 6'-O-nicotinoylalbiflorin (1), 4'-O-vanillylalbiflorin (2), paeonidanin L (3), paeoniflorigenin-1-O-β-d-xyloside (4), 6'-(2-hydroxypropanoyl)-paeoniflorin (5), oxylactiflorin (6), together with 16known ones (7-22) were isolated from the 70% ethanol extract of Paeoniae Radix. Their structures were elucidated based on spectroscopic analysis (1D and 2D NMR, HRESIMS, IR and UV), chemical evidences and comparison with literatures. The inhibitory effects of all the isolates were evaluated against lipopolysaccharide (LPS) stimulated PGE2 production in RAW 264.7 macrophages.

UI MeSH Term Description Entries
D002681 China A country spanning from central Asia to the Pacific Ocean. Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D006027 Glycosides Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed) Glycoside
D000067996 RAW 264.7 Cells A transformed macrophage cell line isolated from ASCITES of mice infected with ABELSON MURINE LEUKEMIA VIRUS. RAW 264.7 Cell Line,264.7 Cell, RAW,264.7 Cells, RAW,Cell, RAW 264.7,Cells, RAW 264.7,RAW 264.7 Cell
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents
D015394 Molecular Structure The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds. Structure, Molecular,Molecular Structures,Structures, Molecular
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D018517 Plant Roots The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990) Plant Bulbs,Plant Root,Bulb, Plant,Bulbs, Plant,Plant Bulb,Root, Plant,Roots, Plant
D029596 Paeonia A plant genus of the family Paeoniaceae, order Dilleniales, subclass Dilleniidae, class Magnoliopsida. These perennial herbs are up to 2 m (6') tall. Leaves are alternate and are divided into three lobes, each lobe being further divided into three smaller lobes. The large flowers are symmetrical, bisexual, have 5 sepals, 5 petals (sometimes 10), and many stamens. Paeoniae Radix,Peony,Shakuyaku,Paeoniae Radices,Paeonias,Peonies,Radices, Paeoniae,Radix, Paeoniae,Shakuyakus

Related Publications

Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
New bioactive monoterpene glycosides from Paeoniae Radix.
June 1996, Chemical & pharmaceutical bulletin,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
[Analysis of variation of monoterpene glycosides and polyhydroxy compounds in paeoniae radix alba during preliminary processing].
May 2014, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
Antipyretic activity of Radix paeoniae.
July 2007, Ancient science of life,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
[Metabolomics study of anti-inflammatory action of Radix Paeoniae Rubra and Radix Paeoniae Alba by ultraperformance liquid chromatography-mass spectrometry].
March 2011, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
New monoterpene glycosides from the root cortex of Paeonia suffruticosa and their potential anti-inflammatory activity.
January 2014, Natural product research,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
Study on anti-tumor effect of total glycosides from Radix paeoniae rubra in S180 tumor-bearing mice.
January 2013, African journal of traditional, complementary, and alternative medicines : AJTCAM,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
A novel method HPLC-DAD analysis of the Contentsof Moutan Cortexand Paeoniae Radix Alba with similar constituents-monoterpene glycosides in Guizhi Fuling Wan.
November 2014, Molecules (Basel, Switzerland),
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
[Quality evaluation on Paeoniae radix. I. Quantitative analysis of monoterpene glycosides constituents of Paeoniae radix by means of high performance liquid chromatography. Comparative characterization of the external figures, processing method and the cultivated areas].
February 1996, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
[Metabolomics study of anti-platelet effect of Radix Paeoniae Rubra and Radix Paeoniae Alba by UPLC-MS].
March 2011, Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica,
Hai-Bo Li, and Ying Shi, and Qianqian Pang, and Yudan Mei, and Zhenzhen Su, and Xin-Sheng Yao, and Yang Yu
Anti-PTSD-like effects of albiflorin extracted from Radix paeoniae Alba.
February 2017, Journal of ethnopharmacology,
Copied contents to your clipboard!