[DSP 4, a neurotoxic agent that destroys noradrenergic endings, selectively increases "expectancy" in the cat]. 1988

D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
Institut des Neurosciences, U.A. n. 1199, C.N.R.S., Université Pierre-et-Marie-Curie, Département de Neurophysiologie comparée, Paris.

Cats were treated with DSP 4, a neurotoxic agent known to destroy central noradrenergic endings. A significant increase was subsequently noticed in the amount of time spent by the treated animals in an attitude of "expectancy", i.e. of motionless waiting for an "event to occur". They even developed this attitude when no such real situation existed. Concomitantly, an increase was noticed in the power of the 14 Hz electrocortical rhythms recorded over the somatic sensory cortex. These patterns, designated as "mu" rhythms, had previously been shown to characterize this particular type of attentive state. The present data tends to confirm our previous hypothesis, that immobile expectancy and its accompanying electrocortical pattern are under a noradrenergic inhibitory control.

UI MeSH Term Description Entries
D009411 Nerve Endings Branch-like terminations of NERVE FIBERS, sensory or motor NEURONS. Endings of sensory neurons are the beginnings of afferent pathway to the CENTRAL NERVOUS SYSTEM. Endings of motor neurons are the terminals of axons at the muscle cells. Nerve endings which release neurotransmitters are called PRESYNAPTIC TERMINALS. Ending, Nerve,Endings, Nerve,Nerve Ending
D009498 Neurotoxins Toxic substances from microorganisms, plants or animals that interfere with the functions of the nervous system. Most venoms contain neurotoxic substances. Myotoxins are included in this concept. Alpha-Neurotoxin,Excitatory Neurotoxin,Excitotoxins,Myotoxin,Myotoxins,Neurotoxin,Alpha-Neurotoxins,Excitatory Neurotoxins,Excitotoxin,Alpha Neurotoxin,Alpha Neurotoxins,Neurotoxin, Excitatory,Neurotoxins, Excitatory
D002415 Cats The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801) Felis catus,Felis domesticus,Domestic Cats,Felis domestica,Felis sylvestris catus,Cat,Cat, Domestic,Cats, Domestic,Domestic Cat
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001288 Attention Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating. Focus of Attention,Selective Attention,Social Attention,Attention Focus,Attention, Selective,Attention, Social,Selective Attentions
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D001596 Benzylamines Toluenes in which one hydrogen of the methyl group is substituted by an amino group. Permitted are any substituents on the benzene ring or the amino group. Phenylmethylamine,alpha-Aminotoluene,alpha Aminotoluene

Related Publications

D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
January 1996, Brain, behavior and evolution,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
April 2008, Behavioural brain research,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
April 1980, Brain research,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
January 1989, Neuroscience,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
October 1979, Life sciences,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
December 1978, The Journal of physiology,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
April 1998, Psychopharmacology,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
January 2016, Chembiochem : a European journal of chemical biology,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
April 1983, Pharmacology, biochemistry, and behavior,
D Tadjer, and P Delagrange, and J J Bouyer, and C Durand, and A Rougeul
January 1983, Psychopharmacology,
Copied contents to your clipboard!