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[Pre- and post-operative adjuvant chemotherapy of colorectal cancer. Part 1. Drug concentration in tissues following UFT administration]. 1988
M Tomita, and
T Shimoyama, and
T Hirano, and
T Nakagoe, and
T Shimizu, and
H Kusano, and
Y Fukuda, and
K Eida, and
T Ishii, and
Y Kotake
1st Dept. of Surgery, School of Medicine Nagasaki University.
The concentration of Tegafur, 5-FU and Uracil in tumor and normal tissue were measured in 47 colorectal cancer patients who had been administered UFT (400/mg) for seven days before operation. The concentration of Tegafur, 5-FU and Uracil in tumor was higher than in normal tissue (p less than 0.01), and the concentration of 5-FU was correlative to the concentration of Tegafur and Uracil in both tissues. The Dukes group and histological type were not related to the concentration of Tegafur, 5-FU and Uracil in either tissue. The uptake of each drug was good and high in tumor tissue.
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