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The Malaria Cell Atlas: Single parasite transcriptomes across the complete Plasmodium life cycle. 2019
Virginia M Howick, and
Andrew J C Russell, and
Tallulah Andrews, and
Haynes Heaton, and
Adam J Reid, and
Kedar Natarajan, and
Hellen Butungi, and
Tom Metcalf, and
Lisa H Verzier, and
Julian C Rayner, and
Matthew Berriman, and
Jeremy K Herren, and
Oliver Billker, and
Martin Hemberg, and
Arthur M Talman, and
Mara K N Lawniczak
Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK.
Malaria parasites adopt a remarkable variety of morphological life stages as they transition through multiple mammalian host and mosquito vector environments. We profiled the single-cell transcriptomes of thousands of individual parasites, deriving the first high-resolution transcriptional atlas of the entire Plasmodium berghei life cycle. We then used our atlas to precisely define developmental stages of single cells from three different human malaria parasite species, including parasites isolated directly from infected individuals. The Malaria Cell Atlas provides both a comprehensive view of gene usage in a eukaryotic parasite and an open-access reference dataset for the study of malaria parasites.
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