Application of orthogonal functions to the spectrophotometric determination of calciferol in oily injections. 1979

S M Hassan

The method of orthogonal functions has been applied to the rapid spectrophotometric determination of vitamin D in oily injections. The method involves saponification of the sample and extraction of the unsaponifiable matter with ether. After cautious evaporation of ether, the residue is dissolved in isopropanol and the absorbance of the solution is measured in the range 246--296 nm at 10 nm intervals. For BPC injections, the saponification step may be omitted. A suitable dilution of the sample in isopropanol is measured in the range 250.5--300.5 nm at 10 nm intervals. Accurate and precise results are obtained in both cases.

UI MeSH Term Description Entries
D007267 Injections Introduction of substances into the body using a needle and syringe. Injectables,Injectable,Injection
D009821 Oils Unctuous combustible substances that are liquid or easily liquefiable on warming, and are soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils. Depending on their behavior on heating, they are volatile or fixed. (Dorland, 28th ed)
D004872 Ergocalciferols Derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24. Calciferols,Vitamin D 2,Ergocalciferol,Vitamin D2,D2, Vitamin
D012996 Solutions The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed) Solution
D013056 Spectrophotometry, Ultraviolet Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Ultraviolet Spectrophotometry

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