BIOMAT Database Logo BIOMAT Database Logo

[Radiotherapy in Ewing sarcoma: current results of the German Society of Pediatric Oncology studies CESS 81 and CESS 86]. 1988

J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Strahlentherapeutische Klinik der Universität Erlangen-Nürnberg.

In CESS 81 the rate of local recurrences was high particularly in patients with radiation for local control. To improve the safety of local control, in the follow-up study CESS 86 chemotherapy for high risk patients was intensified. The combination of surgery with postoperative radiation was favoured when possible, local control was brought forward from week 18 to week 9, the doses of postoperative radiotherapy was increased from 36 to 46 Gy, and a radiation planning center was established for centralized planning of radiotherapy on the basis of tumor extension at diagnosis. In addition patients with radiation were randomized for conventional fractionation or a scheme of accelerated split course hyperfractionation with simultaneous chemotherapy. Preliminary results of 76 CESS 86 patients (incl. pilot phase), show a lowered rate of local recurrences compared to CESS 81: 6% local recurrences and 15% local recurrences in patients with radiation. With selection of patients with small and chemoresponsive tumors for radiotherapy no longer a disadvantage was seen for patients with radiotherapy concerning the safety of local control.

UI MeSH Term Description Entries
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D011882 Radiotherapy, High-Energy Radiotherapy using high-energy (megavolt or higher) ionizing radiation. Types of radiation include gamma rays, produced by a radioisotope within a teletherapy unit; x-rays, electrons, protons, alpha particles (helium ions) and heavy charged ions, produced by particle acceleration; and neutrons and pi-mesons (pions), produced as secondary particles following bombardment of a target with a primary particle. Megavolt Radiotherapy,High-Energy Radiotherapy,Radiotherapy, Megavolt,High Energy Radiotherapy,Radiotherapy, High Energy
D001859 Bone Neoplasms Tumors or cancer located in bone tissue or specific BONES. Bone Cancer,Cancer of Bone,Cancer of the Bone,Neoplasms, Bone,Bone Neoplasm,Neoplasm, Bone
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D003131 Combined Modality Therapy The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. Multimodal Treatment,Therapy, Combined Modality,Combined Modality Therapies,Modality Therapies, Combined,Modality Therapy, Combined,Multimodal Treatments,Therapies, Combined Modality,Treatment, Multimodal,Treatments, Multimodal
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000971 Antineoplastic Combined Chemotherapy Protocols The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form. Anticancer Drug Combinations,Antineoplastic Agents, Combined,Antineoplastic Chemotherapy Protocols,Antineoplastic Drug Combinations,Cancer Chemotherapy Protocols,Chemotherapy Protocols, Antineoplastic,Drug Combinations, Antineoplastic,Antineoplastic Combined Chemotherapy Regimens,Combined Antineoplastic Agents,Agent, Combined Antineoplastic,Agents, Combined Antineoplastic,Anticancer Drug Combination,Antineoplastic Agent, Combined,Antineoplastic Chemotherapy Protocol,Antineoplastic Drug Combination,Cancer Chemotherapy Protocol,Chemotherapy Protocol, Antineoplastic,Chemotherapy Protocol, Cancer,Chemotherapy Protocols, Cancer,Combinations, Antineoplastic Drug,Combined Antineoplastic Agent,Drug Combination, Anticancer,Drug Combination, Antineoplastic,Drug Combinations, Anticancer,Protocol, Antineoplastic Chemotherapy,Protocol, Cancer Chemotherapy,Protocols, Antineoplastic Chemotherapy,Protocols, Cancer Chemotherapy
D012512 Sarcoma, Ewing A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones. The tumor occurs usually before the age of 20, about twice as frequently in males as in females. Ewing's Tumor,Sarcoma, Ewing's,Ewing Sarcoma,Ewing Tumor,Ewing's Sarcoma,Ewings Sarcoma,Ewings Tumor,Sarcoma, Ewings,Tumor, Ewing,Tumor, Ewing's

Related Publications

J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
[The German Society of Pediatric Oncology Cooperative Ewing Sarcoma Studies CESS 81/86: report after 6 1/2 years].
January 1988, Klinische Padiatrie,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
[The Cooperative Ewing Sarcoma Study CESS 81 of the German Pediatric Oncology Society--analysis after 4 years].
January 1985, Klinische Padiatrie,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
[The CESS 81 cooperative Ewing sarcoma study of the Society for Pediatric Oncology: an interim report].
January 1983, Klinische Padiatrie,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Radiotherapy in Ewing's sarcoma and PNET of the chest wall: results of the trials CESS 81, CESS 86 and EICESS 92.
December 1998, International journal of radiation oncology, biology, physics,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Local therapy in localized Ewing tumors: results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials.
January 2003, International journal of radiation oncology, biology, physics,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Radiotherapy in Ewing tumors of the vertebrae: treatment results and local relapse analysis of the CESS 81/86 and EICESS 92 trials.
December 2005, International journal of radiation oncology, biology, physics,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Localized Ewing tumor of bone: final results of the cooperative Ewing's Sarcoma Study CESS 86.
March 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
[Cooperative Ewing's Sarcoma Studies 81/86: pathologico-anatomic and immunohistochemical findings and differential diagnosis of Ewing sarcoma].
January 1988, Klinische Padiatrie,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Nonmetastatic pelvic Ewing sarcoma: report of the French society of pediatric oncology.
November 1999, Medical and pediatric oncology,
J Dunst, and R Sauer, and J M Burgers, and R Hawliczek, and R Kürten, and R P Müller, and M Wannenmacher, and H Jürgens
Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study.
March 1999, Medical and pediatric oncology,
Copied contents to your clipboard!