Biomaterial Database

Effects of Commercially Available Whitening Creams on the Epidermal Thickness of Guinea Pig Skin. 2019

Sadia Saqib, and Rafeea Tafweez, and Nadia Haq, and Mah-Jabeen Muneera

Department of Anatomy, King Edward Medical University, Lahore, Pakistan.

OBJECTIVE To determine the effects of commonly used commercial skin lightening creams on the thickness of epidermis of guinea pig skin. METHODS Animal experimental study. METHODS Department of Anatomy, King Edward Medical University, Lahore, from March to May 2015. METHODS Forty-eight adult, colored guinea pigs were used in this study. The animals were randomly divided into four groups. Group I was control group (no cream application). The animals of group II, III and IV were treated with skin whitening creams A, B and C respectively once daily, 6 days/week for eight weeks duration. The observations of skin specimens were made after 4 and 8 weeks for epidermal thickness at histological level. RESULTS Microscopic examination showed variable degrees of epidermal thickening with the three creams applied for 4 weeks. The increase in thickness of epidermis ranged from 49.1 μm in control group to maximum of 106.4 μm in group ll. These effects were further intensified after 8 weeks application. CONCLUSIONS The use of whitening creams caused skin damage by increasing the epidermal thickness of varying extent.

UI	MeSH Term	Description	Entries
D004817	Epidermis	The external, nonvascular layer of the skin. It is made up, from within outward, of five layers of EPITHELIUM: (1) basal layer (stratum basale epidermidis); (2) spinous layer (stratum spinosum epidermidis); (3) granular layer (stratum granulosum epidermidis); (4) clear layer (stratum lucidum epidermidis); and (5) horny layer (stratum corneum epidermidis).
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D062327	Skin Lightening Preparations	Substances used to obtain a lighter skin complexion or to treat HYPERPIGMENTATION disorders.	Depigmenting Agents,Skin Bleaching Agents,Skin Depigmenting Agents,Skin Whitening Agents,Agent, Depigmenting,Agent, Skin Bleaching,Agent, Skin Depigmenting,Agent, Skin Whitening,Agents, Depigmenting,Agents, Skin Bleaching,Agents, Skin Depigmenting,Agents, Skin Whitening,Bleaching Agent, Skin,Bleaching Agents, Skin,Depigmenting Agent,Depigmenting Agent, Skin,Depigmenting Agents, Skin,Lightening Preparation, Skin,Lightening Preparations, Skin,Preparation, Skin Lightening,Preparations, Skin Lightening,Skin Bleaching Agent,Skin Depigmenting Agent,Skin Lightening Preparation,Skin Whitening Agent,Whitening Agent, Skin,Whitening Agents, Skin
D063465	Skin Cream	A water-soluble medicinal preparation applied to the skin.	Dermal Cream,Skin Lotion,Cream, Dermal,Cream, Skin,Creams, Dermal,Creams, Skin,Dermal Creams,Lotion, Skin,Lotions, Skin,Skin Creams,Skin Lotions