-transparent.png){kind=logo}
A number of reports have described enhanced therapeutic activity of 5-fluorouracil (5-FU) when combined with high-dose folinic acid (dl-CF). In the present phase-II study 35 patients with colorectal cancer were entered into a first-line chemotherapeutic protocol consisting of dl-CF 200 mg/m2 i.v. push directly followed by 340 mg/m2 5-FU i.v. pushon - days 1-5. Thus far a response rate of 37.5% (12 PR) has been achieved, and minor responses or no change were registered in 43.7% (14 MR or NC), lowering the rate of primary therapeutic failures to 18.8%. Median time to progression was 6.2 months. Toxic side effects consisted mainly of diarrhea, nausea and mucositis. As second-line therapy 5-FU/dl-CF and dipyramidole p.o. were administered to 10 patients with resulting 4 NC. Mitomycin C was given to 9 patients as a third-line regimen with resulting 5 NC for 2-4 months.
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 1993,
Cancer chemotherapy and pharmacology,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
September 1987,
Journal of clinical oncology : official journal of the American Society of Clinical Oncology,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 1988,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
April 2001,
Annals of oncology : official journal of the European Society for Medical Oncology,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 1996,
The Journal of infusional chemotherapy,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 1992,
European journal of cancer (Oxford, England : 1990),
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 1998,
La Clinica terapeutica,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
January 2005,
Oncology,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
October 2002,
Cancer chemotherapy and pharmacology,
F Migeod, and
D Gerlach, and
M Kress, and
W Hoffmann, and
R Farroukh, and
S Seeber
October 1995,
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology,
