Biomaterial Database

Cellular changes in the spleens of mice infected with Sarcocystis muris. 1988

H S Gill, and W A Charleston, and K M Moriarty

Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand.

Cellular changes in the spleens of mice infected with Sarcocystis muris have been studied. Immunofluorescent staining for B and T cells and alpha-naphthyl acetate esterase (ANAE) staining for macrophages combined with histological studies revealed marked changes in the populations and distributions of all three cell types. Infection was accompanied by a marked splenomegaly, attributable mainly to widespread hyperplasia of the white pulp. Following infection there was an increase in the relative proportions of B cells (i.e. surface immunoglobulin+) and ANAE+ cells and a decrease in the proportion of T cells (i.e. Thy 1.2+). There was also a progressive accumulation of immunoglobulin-containing cells in the periarteriolar lymphocytic sheaths. Splenomegaly was most pronounced 20 days after infection. At this time there were 9.3 times as many B cells, 3.7 times as many T cells and 16.6 times as many ANAE+ cells as in uninfected mice.

UI	MeSH Term	Description	Entries
D007121	Immunocompetence	The ability of lymphoid cells to mount a humoral or cellular immune response when challenged by antigen.	Competence, Immunologic,Immunologic Competence,Immunological Competence,Competence, Immunological
D009929	Organ Size	The measurement of an organ in volume, mass, or heaviness.	Organ Volume,Organ Weight,Size, Organ,Weight, Organ
D002452	Cell Count	The number of CELLS of a specific kind, usually measured per unit volume or area of sample.	Cell Density,Cell Number,Cell Counts,Cell Densities,Cell Numbers,Count, Cell,Counts, Cell,Densities, Cell,Density, Cell,Number, Cell,Numbers, Cell
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001402	B-Lymphocytes	Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.	B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent
D012523	Sarcocystosis	Infection of the striated muscle of mammals by parasites of the genus SARCOCYSTIS. Disease symptoms such as vomiting, diarrhea, muscle weakness, and paralysis are produced by sarcocystin, a toxin produced by the organism.	Sarcosporidiosis,Sarcocystoses,Sarcosporidioses
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013601	T-Lymphocytes	Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.	T Cell,T Lymphocyte,T-Cells,Thymus-Dependent Lymphocytes,Cell, T,Cells, T,Lymphocyte, T,Lymphocyte, Thymus-Dependent,Lymphocytes, T,Lymphocytes, Thymus-Dependent,T Cells,T Lymphocytes,T-Cell,T-Lymphocyte,Thymus Dependent Lymphocytes,Thymus-Dependent Lymphocyte
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus