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Various bifunctional reagents by the free NH2 group of ristomycinic acid of ristomycin A were used for selective chemical modification of the antibiotic. The bifunctional reagents were the following: di-N-hydroxysuccinimide ether of suberic acid and 4,4'-difluoro-3,3'-dinitrodiphenylsulfone. Bis-N,N'-derivatives of ristomycin A were prepared using these reagents. The derivatives inhibited the growth of Bac. subtilis but the concentrations required for the inhibition were 2-4 times higher than those of ristomycin A. It was noted that the MIC of the bis-N,N'-derivatives depended on the length and flexibility of the "binding foot". The MIC of the bis-N,N'-derivative prepared with using suberic acid was 2 times higher than that of the derivative prepared with the use of 4,4'-difluoro-3,3'-dinitrodiphenylsulfone.
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
January 1987,
Acta haematologica,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
August 1979,
The Journal of general virology,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
March 1987,
European journal of biochemistry,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
September 1973,
Zeitschrift fur Immunitatsforschung, experimentelle und klinische Immunologie,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
January 1982,
Methods in enzymology,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
January 1983,
Methods in enzymology,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
June 2010,
The Journal of organic chemistry,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
October 1986,
Gematologiia i transfuziologiia,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
January 1972,
Methods in enzymology,
Zh P Trifonova, and
N V Sturman, and
G S Katrukha, and
G B Fedorova
February 1967,
Antibiotiki,
