-transparent.png){kind=logo}
Goat lung surfactant for treatment of respiratory distress syndrome among preterm neonates: a multi-site randomized non-inferiority trial. 2019
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
All India Institute of Medical Sciences (AIIMS), New Delhi, India.
To investigate the safety and efficacy of goat lung surfactant extract (GLSE) compared with bovine surfactant extract (beractant; Survanta®, AbbVie, USA) for the treatment of neonatal respiratory distress syndrome (RDS). We conducted a double-blind, non-inferiority, randomized trial in seven Indian centers between June 22, 2016 and January 11, 2018. Preterm neonates of 26 to 32 weeks gestation with clinical diagnosis of RDS were randomized to receive either GLSE or beractant. Repeat dose, if required, was open-label beractant in both the groups. The primary outcome was a composite of death or bronchopulmonary dysplasia (BPD) at 36 weeks postmenstrual age (PMA). Interim analyses were done by an independent data and safety monitoring board (DSMB). After the first interim analyses on 5% enrolment, the "need for repeat dose(s) of surfactant" was added as an additional primary outcome and enrolment restricted to intramural births at five of the seven participating centers. Following second interim analysis after 98 (10% of 900 planned) neonates were enroled, DSMB recommended closure of study in view of inferior efficacy of GLSE in comparison to beractant. There was no significant difference in the primary outcome of death or BPD between GLSE group (n = 52) and beractant group (n = 46) (50.0 vs. 39.1%; OR 1.5; 95% CI 0.7-3.5; p = 0.28). The need for repeat dose of surfactant was significantly higher in GLSE group (65.4 vs. 17.4%; OR 9.0; 95% CI 3.5-23.3; p < 0.001). Goat lung surfactant was less efficacious than beractant (Survanta®) for treatment of RDS in preterm infants. Reasons to ascertain inferior efficacy of goat lung surfactant requires investigation and possible mitigating strategies in order to develop a low-cost and effective surfactant.
Related Publications
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
January 2022,
BMC pediatrics,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
January 1994,
Jornal de pediatria,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
September 1991,
American journal of diseases of children (1960),
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
September 2015,
Scientific reports,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
July 2008,
Pediatrics,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
June 2004,
The Journal of pediatrics,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
January 2022,
Archives of disease in childhood. Fetal and neonatal edition,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
February 2001,
Pediatric radiology,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
June 1985,
The Journal of pediatrics,
Kajal Jain, and
Sushma Nangia, and
Vishnu Bhat Ballambattu, and
Venkataseshan Sundaram, and
M Jeeva Sankar, and
Siddharth Ramji, and
Sreenivas Vishnubhatla, and
Anu Thukral, and
Yogendra Kumar Gupta, and
Nishad Plakkal, and
Mangalabharathi Sundaram, and
Mamta Jajoo, and
Praveen Kumar, and
Kumutha Jayaraman, and
Ashish Jain, and
Arvind Saili, and
Anitha Murugesan, and
Deepak Chawla, and
Srinivas Murki, and
Ruchi Nanavati, and
Suman Rao, and
Umesh Vaidya, and
Ashish Mehta, and
Kamal Arora, and
Jayashree Mondkar, and
Sugandha Arya, and
Monika Bahl, and
Alpana Utture, and
Swati Manerkar, and
Swarna Rekha Bhat, and
Tushar Parikh, and
Manish Kumar, and
Anurag Bajpai, and
Sindhu Sivanandan, and
Pawandeep Kaur Dhawan, and
Gayatri Vishwakarma, and
Sudhakar Bangera, and
Sumit Kumar, and
Shridhar Gopalakrishnan, and
Atul Jindal, and
Chandra Kumar Natarajan, and
Anumeet Saini, and
Sukanya Karunanidhi, and
Meenakshi Malik, and
Parul Narang, and
Gurkirat Kaur, and
Chander Prakash Yadav, and
Ashok Deorari, and
Vinod K Paul, and
Ramesh Agarwal
January 2014,
Pediatrics,
