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Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives. 1988
V V Vlassov, and
S A Gaidamakov, and
V F Zarytova, and
D G Knorre, and
A S Levina, and
A A Nikonova, and
L M Podust, and
O S Fedorova
Institute of Bioorganic Chemistry, Siberian Division of the Academy of Sciences of U.S.S.R., Novosibirsk.
Chemical modification of double-stranded (ds) DNA with alkylating oligodeoxynucleotide (oligo) derivatives, 5'-p(N-2-chloroethyl-N-methylamino) benzylamides of oligos, has been investigated. In contrast to relaxed plasmid DNAs, the superhelical molecules interact with the oligo derivatives and specific alkylation of the DNAs occurs at the regions complementary to the oligo reagents. Alkylating derivatives of oligocytidylates and pT(pCpT)6 react with corresponding homopyrimidine-homopurine tracts within ds DNA fragments due to triple helix formation.
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