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The effects of various inducers on the activities of drug-metabolizing enzymes including aflatoxin B1 activation were studied in Syrian golden hamsters. Activity for aflatoxin B1 was determined by aflatoxin B1-DNA adducts formation. The treatments of hamsters with 3-methylcholanthrene, alpha-naphthoflavone and benzo(a)pyrene elevated markedly the activity for aflatoxin B1 by 2460, 1380 and 450%, respectively. Phenobarbital induced slightly and isosafrole and ethanol did not induce the activity for aflatoxin B1. Pregnenolone-16 alpha-carbonitrile decreased aflatoxin B1 activation to 51% of that of the non-treated animals. These results were in good accordance with the induction rate of a form of cytochrome P-450 (P-450AFB) which has potent activity to aflatoxin B1. Characteristics in the induction of mixed function oxidases of hamsters by these inducers, especially in respect to benzo(a) pyrene metabolizing enzyme, seemed to differ from those of rats. These results suggest that the activity for aflatoxin B1 in hamster is inducible by 3-methylcholanthrene-type inducers and that hamster is a suitable animals model to study the mechanism of aflatoxin B1-hepatocarcinogenesis.
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
January 1994,
Voprosy pitaniia,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
October 1987,
Toxicology and applied pharmacology,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
September 1989,
Mutation research,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
June 1982,
Biochemical pharmacology,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
June 1986,
Mutation research,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
October 1984,
The Journal of biological chemistry,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
January 1965,
Federation proceedings,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
April 1989,
Toxicology and applied pharmacology,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
March 1982,
Cancer research,
M Sunouchi, and
M Fukuhara, and
Y Ohno, and
A Takanaka
February 2000,
Brain research,
