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We have studied eight children with primary hypothyroidism (6F, 2M) aged 6.7 to 14.2 years. The girls were prepubertal and the boys had early normal pubertal development. Overnight secretion of LH, FSH, TSH, PRL and GH, and ovarian ultrasound morphology were assessed before and up to 9 months after commencing thyroxine treatment. Serum FSH concentrations in all the girls were increased above LH levels and severe hypothyroidism was associated with reduced GH secretion. These abnormalities reversed with thyroxine treatment. The boys had less severe hypothyroidism and did not demonstrate abnormal gonadotropin or GH secretion. We conclude that primary hypothyroidism in childhood is associated with widespread disturbance of pituitary function, including increased FSH secretion often without signs of early sexual maturation.
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
March 1995,
Nihon Naibunpi Gakkai zasshi,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
November 1981,
Gut,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
February 2008,
Domestic animal endocrinology,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
February 2005,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
November 1981,
Fertility and sterility,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
March 1969,
The Journal of clinical endocrinology and metabolism,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
September 1983,
Clinical endocrinology,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
May 1977,
Casopis lekaru ceskych,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
December 1967,
The Journal of clinical endocrinology and metabolism,
C R Buchanan, and
R Stanhope, and
P Adlard, and
J Jones, and
D B Grant, and
M A Preece
January 1989,
Acta paediatrica Scandinavica,
