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Platelets of migraine patients showed abnormal behavior such as hyperaggregability and reduced monoamine oxidase activity (MAO). We measured the MAO activity, serotonin (5-HT) content and release, adenosine diphosphate (ADP)-induced aggregation, and the prostacyclin (PGI2) antiaggregatory effect using the same sample of platelets from migraine patients to find out if these characteristics are intercorrelated. A significant correlation between MAO activity and sensitivity to PGI2 was found.
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