Palindromic rheumatism. II. Failure to detect circulating immune complexes during acute episodes. 1979

B Thompson, and I Mohammed, and E J Holborow, and H L Currey

Thirty-eight samples of blood and 2 of synovial fluid were obtained from 19 patients suffering from palindromic rheumatism. In 12 cases samples were obtained from the same patient both during and between acute attacks. The presence of immune complexes was sought by a C1q-binding test. Most patients gave negative results: moderately elevated levels were obtained in a few. Broadly the pattern of results showed that individual patients were either positive or negative irrespective of whether they were in an attack or in remission. C3 and C4 measurements showed no significant abnormalities, confirming previous studies. Patients with elevated C1q-binding tests tended to be seropositive. We speculate that these are patients more likely to develop rheumatoid arthritis.

UI MeSH Term Description Entries
D012008 Recurrence The return of a sign, symptom, or disease after a remission. Recrudescence,Relapse,Recrudescences,Recurrences,Relapses
D003176 Complement C3 A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. C3 Complement,C3 Precursor,Complement 3,Complement C3 Precursor,Complement Component 3,Precursor-Complement 3,Pro-C3,Pro-Complement 3,C3 Precursor, Complement,C3, Complement,Complement, C3,Component 3, Complement,Precursor Complement 3,Precursor, C3,Precursor, Complement C3,Pro C3,Pro Complement 3
D003181 Complement C4 A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B. C4 Complement,C4 Complement Component,Complement 4,Complement C4, Precursor,Complement Component 4,Pro-C4,Pro-complement 4,C4, Complement,Complement Component, C4,Complement, C4,Component 4, Complement,Component, C4 Complement,Pro C4,Pro complement 4
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000208 Acute Disease Disease having a short and relatively severe course. Acute Diseases,Disease, Acute,Diseases, Acute
D000936 Antigen-Antibody Complex The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES. Immune Complex,Antigen-Antibody Complexes,Immune Complexes,Antigen Antibody Complex,Antigen Antibody Complexes,Complex, Antigen-Antibody,Complex, Immune,Complexes, Antigen-Antibody,Complexes, Immune
D012216 Rheumatic Diseases Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement. Rheumatism,Disease, Rheumatic,Diseases, Rheumatic,Rheumatic Disease
D013582 Synovial Fluid The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints. Synovia,Fluid, Synovial,Fluids, Synovial,Synovial Fluids

Related Publications

B Thompson, and I Mohammed, and E J Holborow, and H L Currey
March 1987, Clinical rheumatology,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
September 1979, Clinical allergy,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
May 1984, The Journal of infectious diseases,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
January 1982, Nephron,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
June 1984, Clinical rheumatology,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
March 1993, The Journal of rheumatology,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
September 1966, Henry Ford Hospital medical journal,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
February 2001, Internal medicine (Tokyo, Japan),
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
May 1979, The Journal of allergy and clinical immunology,
B Thompson, and I Mohammed, and E J Holborow, and H L Currey
November 1974, The Journal of experimental medicine,
Copied contents to your clipboard!