Cellulose-based injectable hydrogel composite for pH-responsive and controllable drug delivery. 2019

Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
Department of Agricultural & Biological Engineering, University of Florida, PO Box 110570, Gainesville, FL 32611-0570, United States. Electronic address: n.chen@ufl.edu.

Cellulose-based biocompatible, tunable and injectable hydrogels embedded with pH-responsive diblock copolymer micelles were constructed to achieve localized drug delivery with prolonged, stimuli-driven and slow-release function. First, we prepared two types of modified carboxymethyl cellulose (CMC) including hydrazide-modified carboxymethyl cellulose (CMC-NH2) and oxidized carboxymethyl cellulose (CMC-CHO) with varying degrees of oxidation. Then, pH-responsive poly (ethylene oxide)-block-poly (2-(diisopropylamino) ethyl methacrylate) (PEO-b-PDPA) copolymers as micelle cores to carry hydrophobic substances were also synthesized through atom transfer radical polymerization (ATRP). An injectable hydrogel composite system was finally obtained by mixing CMC-NH2 and CMC-CHO polymer suspensions containing PEO-b-PDPA copolymer micelles through a Schiff base reaction. This newly-synthesized, tunable, cellulose-based double barrier system exhibits a pH-triggered, prolonged, and slow-release profile based on the release test using both Nile Red dye and doxorubicin. The hydrogel system also exhibited comparable storage moduli and tunable degradation properties.

UI MeSH Term Description Entries
D008823 Micelles Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS. Micelle
D011108 Polymers Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS). Polymer
D002266 Carboxymethylcellulose Sodium A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents. Carboxymethyl Cellulose,Carboxymethylcellulose,Aquacel,Aquaplast,Carmellose Sodium,Cellolax,Cethylose,Croscarmellose Sodium,Polycell,Ruspol,Sodium Carboxymethylcellulose,Carboxymethylcellulose, Sodium,Cellulose, Carboxymethyl,Sodium, Carboxymethylcellulose,Sodium, Carmellose,Sodium, Croscarmellose
D004317 Doxorubicin Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN. Adriamycin,Adriablastin,Adriablastine,Adriblastin,Adriblastina,Adriblastine,Adrimedac,DOXO-cell,Doxolem,Doxorubicin Hexal,Doxorubicin Hydrochloride,Doxorubicin NC,Doxorubicina Ferrer Farm,Doxorubicina Funk,Doxorubicina Tedec,Doxorubicine Baxter,Doxotec,Farmiblastina,Myocet,Onkodox,Ribodoxo,Rubex,Urokit Doxo-cell,DOXO cell,Hydrochloride, Doxorubicin,Urokit Doxo cell
D006367 HeLa Cells The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for, among other things, VIRUS CULTIVATION and PRECLINICAL DRUG EVALUATION assays. Cell, HeLa,Cells, HeLa,HeLa Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D006863 Hydrogen-Ion Concentration The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH pH,Concentration, Hydrogen-Ion,Concentrations, Hydrogen-Ion,Hydrogen Ion Concentration,Hydrogen-Ion Concentrations
D016503 Drug Delivery Systems Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity. Drug Targeting,Delivery System, Drug,Delivery Systems, Drug,Drug Delivery System,Drug Targetings,System, Drug Delivery,Systems, Drug Delivery,Targeting, Drug,Targetings, Drug
D057927 Hydrophobic and Hydrophilic Interactions The thermodynamic interaction between a substance and WATER. Hydrophilic Interactions,Hydrophilic and Hydrophobic Interactions,Hydrophilicity,Hydrophobic Interactions,Hydrophobicity,Hydrophilic Interaction,Hydrophilicities,Hydrophobic Interaction,Hydrophobicities,Interaction, Hydrophilic,Interaction, Hydrophobic,Interactions, Hydrophilic,Interactions, Hydrophobic
D058105 Polymerization Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE). Polymerizations

Related Publications

Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
November 2023, Journal of biomaterials applications,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
February 2019, International journal of biological macromolecules,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
May 2016, Colloids and surfaces. B, Biointerfaces,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
May 2021, Advanced healthcare materials,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
January 2024, International journal of biological macromolecules,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
March 2020, ACS applied materials & interfaces,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
July 2023, International journal of biological macromolecules,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
September 2018, RSC advances,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
May 2020, Materials science & engineering. C, Materials for biological applications,
Nusheng Chen, and Hui Wang, and Chen Ling, and Wilfred Vermerris, and Bin Wang, and Zhaohui Tong
May 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V,
Copied contents to your clipboard!