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R3hdml regulates satellite cell proliferation and differentiation. 2019
Kenichi Sakamoto, and
Yasuro Furuichi, and
Masashi Yamamoto, and
Megumi Takahashi, and
Yoshihiro Akimoto, and
Takahiro Ishikawa, and
Takahiko Shimizu, and
Masanori Fujimoto, and
Aki Takada-Watanabe, and
Aiko Hayashi, and
Yoshitaka Mita, and
Yasuko Manabe, and
Nobuharu L Fujii, and
Ryoichi Ishibashi, and
Yoshiro Maezawa, and
Christer Betsholtz, and
Koutaro Yokote, and
Minoru Takemoto
Department of Endocrinology, Hematology, and Gerontology, Chiba University Graduate School of Medicine, Chiba, Japan.
In this study, we identified a previously uncharacterized skeletal satellite cell-secreted protein, R3h domain containing-like (R3hdml). Expression of R3hdml increases during skeletal muscle development and differentiation in mice. Body weight and skeletal muscle mass of R3hdml knockout (KO) mice are lower compared to control mice. Expression levels of cell cycle-related markers, phosphorylation of Akt, and expression of insulin-like growth factor within the skeletal muscle are reduced in R3hdml KO mice compared to control mice. Expression of R3hdml increases during muscle regeneration in response to cardiotoxin (CTX)-induced muscle injury. Recovery of handgrip strength after CTX injection was significantly impaired in R3hdml KO mice, which is rescued by R3hdml. Our results indicate that R3hdml is required for skeletal muscle development, regeneration, and, in particular, satellite cell proliferation and differentiation.
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