-transparent.png){kind=logo}
Cytogenetic studies of chronic myelogenous leukemia (CML) have shown that the majority of hemopoietic cells originate from pluripotential stem cells affected in this disease. Evidence that lymphocytes are also progeny of these stem cells, however, has been indirect. Philadelphia-chromosome-positive leukemic blasts from a 4 10/12-yr-old boy with CML in blast crisis had features characteristic of pre-B leukemic cells, including expression of cytoplasmic IgM and absence of surface immunoglobulin. Additional immunologic, enzymatic, and pharmacologic characterization of these cells supported their pre-B-cell phenotype. Together, these features provide direct evidence for CML stem cell ancestry to lymphocytes of the B-cell lineage.
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
January 1988,
American journal of hematology,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
September 2007,
The Journal of clinical investigation,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
April 1991,
Cancer,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
January 2015,
Indian journal of cancer,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
January 2005,
Acta haematologica,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
June 1981,
Military medicine,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
June 1983,
International journal of cell cloning,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
March 1975,
Blood,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
September 1990,
British journal of haematology,
L B Vogler, and
W M Crist, and
P C Vinson, and
A Sarrif, and
M G Brattain, and
M S Coleman
August 2016,
Journal of pediatric hematology/oncology,
