-transparent.png){kind=logo}
Chemically induced tumors of mice exhibit apparently unique antigenicity upon syngeneic transplantation into appropriately immunized hosts. An in vitro counterpart of this pattern in terms of specificity has not been reported. Data are presented that demonstrate that immune peritoneal exudates contain cells cytotoxic for the specific immunogen tumor but with rare exceptions, not toward other syngeneic methylcholanthrene-induced fibrosarcomas. Only tumors highly immunogenic by transplantation criteria induce cytotoxic PEC regularly; nonimmunogenic tumors consistently fail to do so. The effector cell responsible is eliminated by pretreatment with anti-Thy.1 but not anti-Ig plus complement. In concomitant experiments, PEC populations cytotoxic in vitro also conveyed adoptive protection against the specific tumor in syngeneic hosts. This in vitro assay appears to provide a tool for studying T cell-mediated cytotoxicity toward a set of unique surface antigens present on chemically induced tumors.
P H Chauvenet, and
C P McArthur, and
R T Smith
January 1977,
Advances in pathobiology,
P H Chauvenet, and
C P McArthur, and
R T Smith
June 1971,
Annals of the New York Academy of Sciences,
P H Chauvenet, and
C P McArthur, and
R T Smith
June 1984,
Immunology today,
P H Chauvenet, and
C P McArthur, and
R T Smith
January 1987,
Progress in clinical and biological research,
P H Chauvenet, and
C P McArthur, and
R T Smith
January 1983,
Experientia,
P H Chauvenet, and
C P McArthur, and
R T Smith
January 1990,
International journal of immunopharmacology,
P H Chauvenet, and
C P McArthur, and
R T Smith
March 1969,
International journal of cancer,
P H Chauvenet, and
C P McArthur, and
R T Smith
March 1978,
International journal of cancer,
P H Chauvenet, and
C P McArthur, and
R T Smith
March 1988,
Immunology today,
P H Chauvenet, and
C P McArthur, and
R T Smith
July 1994,
Behring Institute Mitteilungen,
