BIOMAT Database Logo BIOMAT Database Logo

Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice. 2020

Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Persons suffering from opioid use disorder (OUD) experience long-lasting dysphoric symptoms well into extended periods of withdrawal. This protracted withdrawal syndrome is notably characterized by heightened anxiety and hyperkatifeia. Here, we investigated if an exacerbated withdrawal model of acute morphine dependence results in lasting behavioral adaptation 6 weeks into forced abstinence in C57BL/6J mice. We found that our exacerbated morphine withdrawal paradigm produced distinct alterations in behavior in elevated plus maze (EPM), open field, and social interaction tests in male and female mice. Following protracted withdrawal male mice showed enhanced exploration of the open arms of the EPM, reduced latency to enter the corner of the OF, and a social interaction deficit. In contrast, female mice showed enhanced thigmotaxis in the OF. In both sexes, protracted withdrawal enhanced locomotor behavior in response to subsequent morphine challenge, albeit at different doses. These findings will be relevant for future investigation examining the neural mechanisms underlying these behaviors and will aid in uncovering physiological sex differences in response to opioid withdrawal.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009020 Morphine The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle. Morphine Sulfate,Duramorph,MS Contin,Morphia,Morphine Chloride,Morphine Sulfate (2:1), Anhydrous,Morphine Sulfate (2:1), Pentahydrate,Oramorph SR,SDZ 202-250,SDZ202-250,Chloride, Morphine,Contin, MS,SDZ 202 250,SDZ 202250,SDZ202 250,SDZ202250,Sulfate, Morphine
D005260 Female Females
D000701 Analgesics, Opioid Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. Opioid,Opioid Analgesic,Opioid Analgesics,Opioids,Full Opioid Agonists,Opioid Full Agonists,Opioid Mixed Agonist-Antagonists,Opioid Partial Agonists,Partial Opioid Agonists,Agonist-Antagonists, Opioid Mixed,Agonists, Full Opioid,Agonists, Opioid Full,Agonists, Opioid Partial,Agonists, Partial Opioid,Analgesic, Opioid,Full Agonists, Opioid,Mixed Agonist-Antagonists, Opioid,Opioid Agonists, Full,Opioid Agonists, Partial,Opioid Mixed Agonist Antagonists,Partial Agonists, Opioid
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001007 Anxiety Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS. Angst,Anxiousness,Hypervigilance,Nervousness,Social Anxiety,Anxieties, Social,Anxiety, Social,Social Anxieties
D013375 Substance Withdrawal Syndrome Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. Drug Withdrawal Symptoms,Withdrawal Symptoms,Drug Withdrawal Symptom,Substance Withdrawal Syndromes,Symptom, Drug Withdrawal,Symptom, Withdrawal,Symptoms, Drug Withdrawal,Symptoms, Withdrawal,Syndrome, Substance Withdrawal,Syndromes, Substance Withdrawal,Withdrawal Symptom,Withdrawal Symptom, Drug,Withdrawal Symptoms, Drug,Withdrawal Syndrome, Substance,Withdrawal Syndromes, Substance
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice.
February 2023, bioRxiv : the preprint server for biology,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Probing different paradigms of morphine withdrawal on sleep behavior in male and female C57BL/6J mice.
June 2023, Behavioural brain research,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Physiological and behavioral responses to intermittent starvation in C57BL/6J mice.
January 2012, Physiology & behavior,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Differences in Fracture Healing Between Female and Male C57BL/6J Mice.
January 2021, Frontiers in physiology,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Nutritional ketosis as treatment for alcohol withdrawal symptoms in female C57BL/6J mice.
March 2024, Scientific reports,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Behavioral effects of long-term oral administration of aluminum ammonium sulfate in male and female C57BL/6J mice.
March 2018, Neuropsychopharmacology reports,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Behavioural consequences of IVC cages on male and female C57BL/6J mice.
May 2013, Neuroscience,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice.
September 2023, bioRxiv : the preprint server for biology,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Sex differences in binge alcohol drinking and the behavioral consequences of protracted abstinence in C57BL/6J mice.
November 2023, Biology of sex differences,
Isabel M Bravo, and Brennon R Luster, and Meghan E Flanigan, and Patric J Perez, and Elizabeth S Cogan, and Karl T Schmidt, and Zoe A McElligott
Intravenous cocaine self-administration: individual differences in male and female C57BL/6J mice.
January 2007, Pharmacology, biochemistry, and behavior,
Copied contents to your clipboard!