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Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents. 2019
Anastasia L Khandazhinskaya, and
Elena S Matyugina, and
Pavel N Solyev, and
Maggie Wilkinson, and
Karen W Buckheit, and
Robert W Buckheit, and
Larisa N Chernousova, and
Tatiana G Smirnova, and
Sofya N Andreevskaya, and
Khalid J Alzahrani, and
Manal J Natto, and
Sergey N Kochetkov, and
Harry P de Koning, and
Katherine L Seley-Radtke
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, 32 Vavilov St., Moscow 119991, Russia. khandazhinskaya@bk.ru.
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculosis and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.
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