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M73101 and aspirin were evaluated for the effects on prenatal development of progeny in JW-NIBS strain rabbits. Pregnant females were given orally M73101 (0, 50, 120 and 300mg/kg/day) or aspirin (200mg/kg/day) on days 6 to 18 of gestation. They were sacrificed on days 29 of pregnancy and their fetuses were examined for abnormalities. The results were summarized as follows: 1. During the dosing period, females received 300mg/kg of M73101 showed pronounced body weight depression and decrease in food and water intake. But after the dosing period, these influences were not seen. Females received aspirin did not show such phenomena. 2. There were no adverse effects on number of implants, litter size, fetal mortality or fetal weight, and no malformed fetuses attributable to the drugs were seen in each group.
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
August 1979,
The Journal of toxicological sciences,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
September 1979,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
October 1978,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
April 1979,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
March 1979,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
August 1979,
The Journal of toxicological sciences,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
May 1979,
The Journal of toxicological sciences,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
October 1979,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
November 1978,
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
H Tanigawa, and
R Obori, and
H Tanaka, and
J Yoshida, and
T Kosazuma
September 1981,
Journal of pharmacobio-dynamics,
