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Spleen cells from a LEW.AVN rat immunized with cells from an MNR rat were fused with mouse myeloma cells to produce hybrid cell lines. One of these hybridomas produced a monoclonal antibody that was cytotoxic for bone marrow-derived (B) but not thymus-derived (T) cells. The antigen defined by this antibody is determined by a gene linked to the major histocompatibility complex (MHC). The antigen is also present on B cells of most mouse strains and is determined by an MHC-linked gene in this species as well. In both rats and mice, the gene determining the antigen maps within the immune response region of the MHC. All human B-cell lines, but not T-cell lines, and B but not T cells of all human donors tested so far are also positive for this antigen. Among human-mouse somatic cell lines that have lost various human chromosomes, this B-cell antigen is present on all lines that are positive for HLA antigen but is absent from all lines that have lost HLA.
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
June 2019,
Immunotherapy,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
August 1990,
Biochemical and biophysical research communications,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
January 1989,
Leukemia research,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
July 1993,
Japanese journal of cancer research : Gann,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
January 1983,
Microbiology and immunology,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
February 1981,
The Journal of experimental medicine,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
March 1984,
Journal of immunological methods,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
July 1994,
Veterinary immunology and immunopathology,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
January 1984,
Gerontology,
D L Gasser, and
B A Winters, and
J B Haas, and
T J McKearn, and
R H Kennett
June 2008,
The Journal of experimental medicine,
