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The morphology, immunophenotype, cytoenzymatic and functional activities of T lymphocytes from 4 patients with chronic lymphoproliferative disease of T-cell origin were studied. Clonal proliferation was demonstrated by distinctive chromosomal abnormalities involving chromosomes 2 and 14. Patients 1 and 2 were classifiable as OKT4+ T-cell chronic lymphocytic leukaemia (T-CLL) and patient 3 as OKT4+/OKT8+ T-CLL, with helper function in vitro only in patient 1. Patient 4 has low-grade lymphocytosis with benign clinical course, with cells showing morphology of large granular lymphocytes (LGL), and immunophenotype HNK-1+, ER+, Fc gamma receptor+, OKT3+, OKT11+ and OKT8+, as well as natural killer activity, radiosensitive suppressor activity on Ig secretion and responsiveness to PHA; this case was interpreted as LGL leukaemia. This study indicates that a large proportion of cases of true T-CLL may belong to the OKT4 subset, and that extensive investigations should be made of the lymphocytic OKT8+/T gamma forms to characterize them precisely.
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
March 1978,
Blood,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
September 1988,
Indian journal of cancer,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
June 1993,
Leukemia,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
November 1999,
British journal of haematology,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
September 1998,
British journal of haematology,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
December 2010,
Seminars in cancer biology,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
January 1982,
British journal of haematology,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
September 2008,
Best practice & research. Clinical haematology,
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
October 1973,
Lancet (London, England),
L Baldini, and
F Di Padova, and
A Cortelezzi, and
A Neri, and
L Nobili, and
A M Lavezzi, and
A T Maiolo, and
E E Polli
February 1981,
Haematologica,
