The sustainable development goals (SDGs) encompass 17 goals with targets and indicators, collectively striving to improve national, regional, continental, and global development. SDG 8 strives for improved and sustainable economic growth. Africa's population is estimated to increase markedly and rapidly over the next few decades. The African demographic dividend presents opportunities to be harnessed, but several socioeconomic challenges exist that may constrain progress for achieving the SDGs. Poverty and inequality are pervasive in Africa and constrain economic and health gains. SDG 3 aims for good health and well-being for all ages and has 13 targets linked to 26 indicators. Collectively, SDG 3 targets aim to improve health outcomes by reducing mortality, ending epidemics, and preventing diseases to ensure affordable and quality healthcare access for all. The dynamic African health landscape and scarcity of healthcare human capital also present challenges for advancing SDG 3. The implementation of the SDGs presents major and complex challenges but ultimately yields rewards. Advancement across all SDG 3 targets is necessary for the benefit of healthier global citizens.