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In streptozotocin-induced diabetic rats the biliary excretion of total acetaminophen (AA) was reduced to 14.1% of the dose (100 mg/kg i.v.) as compared to 24.6% in controls. This was due to a significant decrease in the amounts of AA-sulfate and AA-glucuronide, whereas the AA-GSH excretion was not altered. These effects were paralleled by a marked decrease in the bile flow in diabetic rats. In hyperthyroid rats (pretreated with 0.1 mg/kg T3 for 4 days) no significant alterations in the total AA or AA-conjugate excretion into bile were observed; moreover bile flow in hyperthyroid rats was in the same range as for controls. In all, known changes in hepatic microsomal or cytosolic enzyme and cosubstrate concentrations during the diabetic or hyperthyroid state do not at all correlate with their influence on the biliary excretion of AA and its conjugates.
C P Siegers, and
W Loeser, and
M Younes
February 1984,
The Journal of pharmacology and experimental therapeutics,
C P Siegers, and
W Loeser, and
M Younes
January 1984,
Pharmacology,
C P Siegers, and
W Loeser, and
M Younes
January 1984,
Drug metabolism and disposition: the biological fate of chemicals,
C P Siegers, and
W Loeser, and
M Younes
November 1986,
The Journal of pharmacology and experimental therapeutics,
C P Siegers, and
W Loeser, and
M Younes
March 1997,
Research communications in molecular pathology and pharmacology,
C P Siegers, and
W Loeser, and
M Younes
January 1955,
Surgical forum,
C P Siegers, and
W Loeser, and
M Younes
August 1951,
Archives of biochemistry and biophysics,
C P Siegers, and
W Loeser, and
M Younes
October 1984,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
C P Siegers, and
W Loeser, and
M Younes
January 1992,
Drug metabolism and disposition: the biological fate of chemicals,
C P Siegers, and
W Loeser, and
M Younes
January 1981,
Journal of hygiene, epidemiology, microbiology, and immunology,
